Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex
Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We ai...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2410 |
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| author | Lais Boralli Razza Pedro Henrique Rodrigues da Silva Geraldo F. Busatto Fábio Luis de Souza Duran Juliana Pereira Stefanie De Smet Izio Klein Tamires A. Zanão Matthias S. Luethi Chris Baeken Marie-Anne Vanderhasselt Carlos Alberto Buchpiguel André Russowsky Brunoni |
| author_facet | Lais Boralli Razza Pedro Henrique Rodrigues da Silva Geraldo F. Busatto Fábio Luis de Souza Duran Juliana Pereira Stefanie De Smet Izio Klein Tamires A. Zanão Matthias S. Luethi Chris Baeken Marie-Anne Vanderhasselt Carlos Alberto Buchpiguel André Russowsky Brunoni |
| author_sort | Lais Boralli Razza |
| collection | DOAJ |
| description | Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required. |
| first_indexed | 2024-03-09T20:39:12Z |
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| id | doaj.art-b09c6b17ead746ea93f7089a19060f49 |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:39:12Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b09c6b17ead746ea93f7089a19060f492023-11-23T23:02:36ZengMDPI AGBiomedicines2227-90592022-09-011010241010.3390/biomedicines10102410Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal CortexLais Boralli Razza0Pedro Henrique Rodrigues da Silva1Geraldo F. Busatto2Fábio Luis de Souza Duran3Juliana Pereira4Stefanie De Smet5Izio Klein6Tamires A. Zanão7Matthias S. Luethi8Chris Baeken9Marie-Anne Vanderhasselt10Carlos Alberto Buchpiguel11André Russowsky Brunoni12Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, BrazilServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, BrazilLaboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, BrazilLaboratório de Neuroimagem em Psiquiatria (LIM-21), Instituto de Psiquiatria, Faculdade de Medicina da Universidade de São Paulo, R. Dr. Ovidio Pires de Campos 785, São Paulo 05403-000, BrazilServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, BrazilDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, BelgiumServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, BrazilServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, BrazilServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, BrazilDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, BelgiumDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, 9000 Ghent, BelgiumDivisão de Medicina Nuclear (LIM-43), Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 01246-904, BrazilServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, BrazilNon-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.https://www.mdpi.com/2227-9059/10/10/2410non-invasive brain stimulation (NIBS)neuroimagingSingle-Photon Emission Computed Tomography (SPECT)combined interventionssynergistic effectdorsolateral prefrontal cortex (DLPFC) |
| spellingShingle | Lais Boralli Razza Pedro Henrique Rodrigues da Silva Geraldo F. Busatto Fábio Luis de Souza Duran Juliana Pereira Stefanie De Smet Izio Klein Tamires A. Zanão Matthias S. Luethi Chris Baeken Marie-Anne Vanderhasselt Carlos Alberto Buchpiguel André Russowsky Brunoni Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex Biomedicines non-invasive brain stimulation (NIBS) neuroimaging Single-Photon Emission Computed Tomography (SPECT) combined interventions synergistic effect dorsolateral prefrontal cortex (DLPFC) |
| title | Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex |
| title_full | Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex |
| title_fullStr | Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex |
| title_full_unstemmed | Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex |
| title_short | Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex |
| title_sort | brain perfusion alterations induced by standalone and combined non invasive brain stimulation over the dorsolateral prefrontal cortex |
| topic | non-invasive brain stimulation (NIBS) neuroimaging Single-Photon Emission Computed Tomography (SPECT) combined interventions synergistic effect dorsolateral prefrontal cortex (DLPFC) |
| url | https://www.mdpi.com/2227-9059/10/10/2410 |
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