Regulation of fetal male germ cell development by members of the TGFβ superfamily
There is now substantial evidence that members of the transforming growth factor-β (TGFβ family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Stem Cell Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506117301411 |
| _version_ | 1819092689041227776 |
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| author | Cassy Spiller Guillaume Burnet Josephine Bowles |
| author_facet | Cassy Spiller Guillaume Burnet Josephine Bowles |
| author_sort | Cassy Spiller |
| collection | DOAJ |
| description | There is now substantial evidence that members of the transforming growth factor-β (TGFβ family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGFβ family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors. |
| first_indexed | 2024-12-21T22:59:36Z |
| format | Article |
| id | doaj.art-b0a01395a2524b46b9bc43daf464ce8f |
| institution | Directory Open Access Journal |
| issn | 1873-5061 1876-7753 |
| language | English |
| last_indexed | 2024-12-21T22:59:36Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-b0a01395a2524b46b9bc43daf464ce8f2022-12-21T18:47:21ZengElsevierStem Cell Research1873-50611876-77532017-10-0124C17418010.1016/j.scr.2017.07.016Regulation of fetal male germ cell development by members of the TGFβ superfamilyCassy Spiller0Guillaume Burnet1Josephine Bowles2School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, AustraliaThere is now substantial evidence that members of the transforming growth factor-β (TGFβ family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGFβ family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors.http://www.sciencedirect.com/science/article/pii/S1873506117301411Germ cellsTGFβActivinsNodalCripto |
| spellingShingle | Cassy Spiller Guillaume Burnet Josephine Bowles Regulation of fetal male germ cell development by members of the TGFβ superfamily Stem Cell Research Germ cells TGFβ Activins Nodal Cripto |
| title | Regulation of fetal male germ cell development by members of the TGFβ superfamily |
| title_full | Regulation of fetal male germ cell development by members of the TGFβ superfamily |
| title_fullStr | Regulation of fetal male germ cell development by members of the TGFβ superfamily |
| title_full_unstemmed | Regulation of fetal male germ cell development by members of the TGFβ superfamily |
| title_short | Regulation of fetal male germ cell development by members of the TGFβ superfamily |
| title_sort | regulation of fetal male germ cell development by members of the tgfβ superfamily |
| topic | Germ cells TGFβ Activins Nodal Cripto |
| url | http://www.sciencedirect.com/science/article/pii/S1873506117301411 |
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