DetoxiProt: an integrated database for detoxification proteins
<p>Abstract</p> <p>Background</p> <p>Detoxification proteins are a class of proteins for degradation and/or elimination of endogenous and exogenous toxins or medicines, as well as reactive oxygen species (ROS) produced by these materials. Most of these proteins are gene...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-11-01
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| Series: | BMC Genomics |
| _version_ | 1818145736246689792 |
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| author | Yang Zhen Yu Ying Yao Lei Li Guangui Wang Lin Hu Yiyao Wei Haibin Wang Li Hammami Riadh Razavi Roxanne Zhong Yang Liang Xufang |
| author_facet | Yang Zhen Yu Ying Yao Lei Li Guangui Wang Lin Hu Yiyao Wei Haibin Wang Li Hammami Riadh Razavi Roxanne Zhong Yang Liang Xufang |
| author_sort | Yang Zhen |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Detoxification proteins are a class of proteins for degradation and/or elimination of endogenous and exogenous toxins or medicines, as well as reactive oxygen species (ROS) produced by these materials. Most of these proteins are generated as a response to the stimulation of toxins or medicines. They are essential for the clearance of harmful substances and for maintenance of physiological balance in organisms. Thus, it is important to collect and integrate information on detoxification proteins.</p> <p>Results</p> <p>To store, retrieve and analyze the information related to their features and functions, we developed the DetoxiProt, a comprehensive database for annotation of these proteins. This database provides detailed introductions about different classes of the detoxification proteins. Extensive annotations of these proteins, including sequences, structures, features, inducers, inhibitors, substrates, chromosomal location, functional domains as well as physiological-biochemical properties were generated. Furthermore, pre-computed BLAST results, multiple sequence alignments and evolutionary trees for detoxification proteins are also provided for evolutionary study of conserved function and pathways. The current version of DetoxiProt contains 5956 protein entries distributed in 628 organisms. An easy to use web interface was designed, so that annotations about each detoxification protein can be retrieved by browsing with a specific method or by searching with different criteria.</p> <p>Conclusions</p> <p>DetoxiProt provides an effective and efficient way of accessing the detoxification protein sequences and other high-quality information. This database would be a valuable source for toxicologists, pharmacologists and medicinal chemists. DetoxiProt database is freely available at <url>http://lifecenter.sgst.cn/detoxiprot/</url>.</p> |
| first_indexed | 2024-12-11T12:08:12Z |
| format | Article |
| id | doaj.art-b0a03619a1ea4fcbbcab01423a3ee792 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-11T12:08:12Z |
| publishDate | 2011-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-b0a03619a1ea4fcbbcab01423a3ee7922022-12-22T01:07:53ZengBMCBMC Genomics1471-21642011-11-0112Suppl 3S210.1186/1471-2164-12-S3-S2DetoxiProt: an integrated database for detoxification proteinsYang ZhenYu YingYao LeiLi GuanguiWang LinHu YiyaoWei HaibinWang LiHammami RiadhRazavi RoxanneZhong YangLiang Xufang<p>Abstract</p> <p>Background</p> <p>Detoxification proteins are a class of proteins for degradation and/or elimination of endogenous and exogenous toxins or medicines, as well as reactive oxygen species (ROS) produced by these materials. Most of these proteins are generated as a response to the stimulation of toxins or medicines. They are essential for the clearance of harmful substances and for maintenance of physiological balance in organisms. Thus, it is important to collect and integrate information on detoxification proteins.</p> <p>Results</p> <p>To store, retrieve and analyze the information related to their features and functions, we developed the DetoxiProt, a comprehensive database for annotation of these proteins. This database provides detailed introductions about different classes of the detoxification proteins. Extensive annotations of these proteins, including sequences, structures, features, inducers, inhibitors, substrates, chromosomal location, functional domains as well as physiological-biochemical properties were generated. Furthermore, pre-computed BLAST results, multiple sequence alignments and evolutionary trees for detoxification proteins are also provided for evolutionary study of conserved function and pathways. The current version of DetoxiProt contains 5956 protein entries distributed in 628 organisms. An easy to use web interface was designed, so that annotations about each detoxification protein can be retrieved by browsing with a specific method or by searching with different criteria.</p> <p>Conclusions</p> <p>DetoxiProt provides an effective and efficient way of accessing the detoxification protein sequences and other high-quality information. This database would be a valuable source for toxicologists, pharmacologists and medicinal chemists. DetoxiProt database is freely available at <url>http://lifecenter.sgst.cn/detoxiprot/</url>.</p> |
| spellingShingle | Yang Zhen Yu Ying Yao Lei Li Guangui Wang Lin Hu Yiyao Wei Haibin Wang Li Hammami Riadh Razavi Roxanne Zhong Yang Liang Xufang DetoxiProt: an integrated database for detoxification proteins BMC Genomics |
| title | DetoxiProt: an integrated database for detoxification proteins |
| title_full | DetoxiProt: an integrated database for detoxification proteins |
| title_fullStr | DetoxiProt: an integrated database for detoxification proteins |
| title_full_unstemmed | DetoxiProt: an integrated database for detoxification proteins |
| title_short | DetoxiProt: an integrated database for detoxification proteins |
| title_sort | detoxiprot an integrated database for detoxification proteins |
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