Model-Based Simulation of Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia

Model-Based Simulation of Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia is the most common malignancy in childhood. Successful treatment requires initial high-intensity chemotherapy, followed by low-intensity oral maintenance therapy with oral 6-mercaptopurine (6MP) and methotrexate (MTX) until 2–3 years after disease onset. However, intra-...

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Bibliographic Details
Main Authors: Felix Jost, Jakob Zierk, Thuy T. T. Le, Thomas Raupach, Manfred Rauh, Meinolf Suttorp, Martin Stanulla, Markus Metzler, Sebastian Sager
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
childhood acute lymphoblastic leukemia
maintenance therapy
6-mercaptopurine
methotrexate
neutropenia
non-linear mixed-effects modeling
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00217/full

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