Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy
Treatment burden is a multidimensional concept, including several aspects of life of patients affected by chronic conditions. It has been poorly explored in people living with HIV (PLHIV). An online anonymous survey of PLHIV taking antiretroviral therapy (ART) was conducted, in order to investigate...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/2/471 |
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| author | Antonella Cingolani Alessandro Tavelli Franco Maggiolo Annalisa Perziano Annalisa Saracino Francesca Vichi Massimo Cernuschi Giovanni Guaraldi Eugenia Quiros-Roldan Antonella Castagna Andrea Antinori Antonella d’Arminio Monforte on behalf of Icona Foundation Study Group |
| author_facet | Antonella Cingolani Alessandro Tavelli Franco Maggiolo Annalisa Perziano Annalisa Saracino Francesca Vichi Massimo Cernuschi Giovanni Guaraldi Eugenia Quiros-Roldan Antonella Castagna Andrea Antinori Antonella d’Arminio Monforte on behalf of Icona Foundation Study Group |
| author_sort | Antonella Cingolani |
| collection | DOAJ |
| description | Treatment burden is a multidimensional concept, including several aspects of life of patients affected by chronic conditions. It has been poorly explored in people living with HIV (PLHIV). An online anonymous survey of PLHIV taking antiretroviral therapy (ART) was conducted, in order to investigate the self-reported correlates of disease burden. HIV Treatment and Diseases Burden (TDB) was investigated with a questionnaire containing 31 items in 7 domains. Respondents were stratified in high burden (H-TDB)/low burden (L-TDB) according to overall HIV TDB mean + 1 standard deviation. Factors associated with H-TDB has been evaluated with a logistic regression model. In total, 531 PLHIV completed the questionnaire. 99 PLHIV had a H-TDB (18.6%). PLHIV with H-TDB were younger (<i>p</i> < 0.001), less frequently on current two drug antiretroviral (ARV) regimens (<i>p</i> = 0.01) and more frequently with plasma HIV-RNA >50 copies/mL (<i>p</i> = 0.04). At multivariable regression analysis, younger age (aOR 1.43, 95%CI 1.14–1.80; <i>p</i> = 0.002), not fully treatment satisfaction (aOR 2.19, 95%CI 1.28–3.74; <i>p</i> = 0.004), the need of a more accurate dialogue with treating physician (aOR 2.29, 95%CI 1.21–4.36, <i>p</i> = 0.01) and a self-declared lower overall Health Status (aOR 1.75, 95%CI 1.33–2.32; <i>p</i> = 0.002) were all associated with a H-TDB. One out of five PLHIV showed a high level of treatment and disease burden. Younger age, not fully satisfaction with ART and need of interaction with a tailored health system should be taken into consideration as correlates of treatment and disease burden in a patient-centered approach, to reduce the negative impact that it can produce on the overall perceived health status of the person. |
| first_indexed | 2024-03-10T01:13:25Z |
| format | Article |
| id | doaj.art-b0a479532dda4417936ff5373b095439 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:13:25Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b0a479532dda4417936ff5373b0954392023-11-23T14:14:36ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111247110.3390/jcm11020471Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in ItalyAntonella Cingolani0Alessandro Tavelli1Franco Maggiolo2Annalisa Perziano3Annalisa Saracino4Francesca Vichi5Massimo Cernuschi6Giovanni Guaraldi7Eugenia Quiros-Roldan8Antonella Castagna9Andrea Antinori10Antonella d’Arminio Monforte11on behalf of Icona Foundation Study GroupInfectious Diseases Unit, Fondazione Policlinico Universitario A. Gemelli—Università Cattolica Del Sacro Cuore, 00168 Rome, ItalyIcona Foundation, 20145 Milan, ItalyDivision of Infectious Diseases, ASST Papa Giovanni XXIII, 24127 Bergamo, ItalyFor CAB Icona Associazione Arcobaleno AIDS ODV, 10135 Torino, ItalyClinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari, ItalyInfectious Diseases Unit 1, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, 50012 Florence, ItalyDepartment of Infectious Diseases, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, 20127 Milan, ItalyDepartment of Infectious Diseases, University Hospital of Modena, 41125 Modena, ItalyUniversity Department of Infectious and Tropical Diseases, University of Brescia, ASST Spedali Civili, 25123 Brescia, ItalyDepartment of Infectious Diseases, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, 20127 Milan, ItalyHIV/AIDS Department, INMI, L. Spallanzani, IRCCS, 00149 Rome, ItalyClinic of Infectious Diseases, Department of Health Sciences, University of Milan, ASST Santi Paolo e Carlo, 20142 Milan, ItalyTreatment burden is a multidimensional concept, including several aspects of life of patients affected by chronic conditions. It has been poorly explored in people living with HIV (PLHIV). An online anonymous survey of PLHIV taking antiretroviral therapy (ART) was conducted, in order to investigate the self-reported correlates of disease burden. HIV Treatment and Diseases Burden (TDB) was investigated with a questionnaire containing 31 items in 7 domains. Respondents were stratified in high burden (H-TDB)/low burden (L-TDB) according to overall HIV TDB mean + 1 standard deviation. Factors associated with H-TDB has been evaluated with a logistic regression model. In total, 531 PLHIV completed the questionnaire. 99 PLHIV had a H-TDB (18.6%). PLHIV with H-TDB were younger (<i>p</i> < 0.001), less frequently on current two drug antiretroviral (ARV) regimens (<i>p</i> = 0.01) and more frequently with plasma HIV-RNA >50 copies/mL (<i>p</i> = 0.04). At multivariable regression analysis, younger age (aOR 1.43, 95%CI 1.14–1.80; <i>p</i> = 0.002), not fully treatment satisfaction (aOR 2.19, 95%CI 1.28–3.74; <i>p</i> = 0.004), the need of a more accurate dialogue with treating physician (aOR 2.29, 95%CI 1.21–4.36, <i>p</i> = 0.01) and a self-declared lower overall Health Status (aOR 1.75, 95%CI 1.33–2.32; <i>p</i> = 0.002) were all associated with a H-TDB. One out of five PLHIV showed a high level of treatment and disease burden. Younger age, not fully satisfaction with ART and need of interaction with a tailored health system should be taken into consideration as correlates of treatment and disease burden in a patient-centered approach, to reduce the negative impact that it can produce on the overall perceived health status of the person.https://www.mdpi.com/2077-0383/11/2/471treatment burdenHIVantiretrovirallong acting |
| spellingShingle | Antonella Cingolani Alessandro Tavelli Franco Maggiolo Annalisa Perziano Annalisa Saracino Francesca Vichi Massimo Cernuschi Giovanni Guaraldi Eugenia Quiros-Roldan Antonella Castagna Andrea Antinori Antonella d’Arminio Monforte on behalf of Icona Foundation Study Group Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy Journal of Clinical Medicine treatment burden HIV antiretroviral long acting |
| title | Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy |
| title_full | Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy |
| title_fullStr | Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy |
| title_full_unstemmed | Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy |
| title_short | Correlates of Treatment and Disease Burden in People Living with HIV (PLHIV) in Italy |
| title_sort | correlates of treatment and disease burden in people living with hiv plhiv in italy |
| topic | treatment burden HIV antiretroviral long acting |
| url | https://www.mdpi.com/2077-0383/11/2/471 |
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