Self-Assembly and Hydrogelation of Peptide Amphiphiles
Seven peptide amphiphiles were successfully synthesized using solid phase peptide synthesis method. Peptide amphiphiles were characterized using matrix assisted laser desorption/ionization (MALDI). Atomic force microscopy (AFM) study showed that peptide amphiphiles having glycine, valine, or proline...
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Format: | Article |
Language: | English |
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Universitas Indonesia
2012-04-01
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Series: | Makara Seri Sains |
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Online Access: | http://journal.ui.ac.id/index.php/science/article/view/1281/1178 |
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author | Wahyudi Priyono Suwarso Riwandi Sihombing Irwansyah |
author_facet | Wahyudi Priyono Suwarso Riwandi Sihombing Irwansyah |
author_sort | Wahyudi Priyono Suwarso |
collection | DOAJ |
description | Seven peptide amphiphiles were successfully synthesized using solid phase peptide synthesis method. Peptide amphiphiles were characterized using matrix assisted laser desorption/ionization (MALDI). Atomic force microscopy (AFM) study showed that peptide amphiphiles having glycine, valine, or proline as linker, self-assembled into 100-200 nm nanofibers structure. According to our research, both peptide amphiphile with positive and negative charges bear similar self-assembly properties. Peptide amphiphile also showed its capability as low molecular weight gelator (LMWG). Peptide amphiphiles bearing C-16 and C-12 as alkyl showed better hydrogelation properties than C-8 alkyl. Five out of seven peptide amphiphiles have minimum gelation concentration (MGC) lower than 1% (w/v). |
first_indexed | 2024-04-12T19:18:28Z |
format | Article |
id | doaj.art-b0a630d7f50f4aeaaf6fd1578eaf20ab |
institution | Directory Open Access Journal |
issn | 1693-6671 |
language | English |
last_indexed | 2024-04-12T19:18:28Z |
publishDate | 2012-04-01 |
publisher | Universitas Indonesia |
record_format | Article |
series | Makara Seri Sains |
spelling | doaj.art-b0a630d7f50f4aeaaf6fd1578eaf20ab2022-12-22T03:19:40ZengUniversitas IndonesiaMakara Seri Sains1693-66712012-04-011615157Self-Assembly and Hydrogelation of Peptide AmphiphilesWahyudi Priyono SuwarsoRiwandi SihombingIrwansyahSeven peptide amphiphiles were successfully synthesized using solid phase peptide synthesis method. Peptide amphiphiles were characterized using matrix assisted laser desorption/ionization (MALDI). Atomic force microscopy (AFM) study showed that peptide amphiphiles having glycine, valine, or proline as linker, self-assembled into 100-200 nm nanofibers structure. According to our research, both peptide amphiphile with positive and negative charges bear similar self-assembly properties. Peptide amphiphile also showed its capability as low molecular weight gelator (LMWG). Peptide amphiphiles bearing C-16 and C-12 as alkyl showed better hydrogelation properties than C-8 alkyl. Five out of seven peptide amphiphiles have minimum gelation concentration (MGC) lower than 1% (w/v).http://journal.ui.ac.id/index.php/science/article/view/1281/1178low molecular weight gelatorMALDIpeptide amphiphileself-assemblysolid phase peptide synthesis |
spellingShingle | Wahyudi Priyono Suwarso Riwandi Sihombing Irwansyah Self-Assembly and Hydrogelation of Peptide Amphiphiles Makara Seri Sains low molecular weight gelator MALDI peptide amphiphile self-assembly solid phase peptide synthesis |
title | Self-Assembly and Hydrogelation of Peptide Amphiphiles |
title_full | Self-Assembly and Hydrogelation of Peptide Amphiphiles |
title_fullStr | Self-Assembly and Hydrogelation of Peptide Amphiphiles |
title_full_unstemmed | Self-Assembly and Hydrogelation of Peptide Amphiphiles |
title_short | Self-Assembly and Hydrogelation of Peptide Amphiphiles |
title_sort | self assembly and hydrogelation of peptide amphiphiles |
topic | low molecular weight gelator MALDI peptide amphiphile self-assembly solid phase peptide synthesis |
url | http://journal.ui.ac.id/index.php/science/article/view/1281/1178 |
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