Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation
Collagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study,...
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| Format: | Article |
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MDPI AG
2017-09-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/10/9/1086 |
| _version_ | 1811269042380472320 |
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| author | Stefanie Böhm Christine Strauß Stefan Stoiber Cornelia Kasper Verena Charwat |
| author_facet | Stefanie Böhm Christine Strauß Stefan Stoiber Cornelia Kasper Verena Charwat |
| author_sort | Stefanie Böhm |
| collection | DOAJ |
| description | Collagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study, a comparison of seven different collagen matrices derived from bovine, equine, and porcine sources was performed. As performance indicators, the scaffold function for fibroblasts and platelet aggregation were used. We found strong variation in platelet aggregation and fibroblast growth on the different collagen materials. The observed variations could not be attributed to species differences alone, but were highly dependent on differences in the manufacturing process. |
| first_indexed | 2024-04-12T21:33:52Z |
| format | Article |
| id | doaj.art-b0a6c019ad6e42a082afdd3145be31e6 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-04-12T21:33:52Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-b0a6c019ad6e42a082afdd3145be31e62022-12-22T03:15:58ZengMDPI AGMaterials1996-19442017-09-01109108610.3390/ma10091086ma10091086Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet AggregationStefanie Böhm0Christine Strauß1Stefan Stoiber2Cornelia Kasper3Verena Charwat4Technical Chemistry, Leibniz University Hannover, 30167 Hannover, GermanyDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, AustriaDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, AustriaTechnical Chemistry, Leibniz University Hannover, 30167 Hannover, GermanyDepartment of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, AustriaCollagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study, a comparison of seven different collagen matrices derived from bovine, equine, and porcine sources was performed. As performance indicators, the scaffold function for fibroblasts and platelet aggregation were used. We found strong variation in platelet aggregation and fibroblast growth on the different collagen materials. The observed variations could not be attributed to species differences alone, but were highly dependent on differences in the manufacturing process.https://www.mdpi.com/1996-1944/10/9/1086collagen scaffoldsfibroblastsplatelet aggregation3D cell culture |
| spellingShingle | Stefanie Böhm Christine Strauß Stefan Stoiber Cornelia Kasper Verena Charwat Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation Materials collagen scaffolds fibroblasts platelet aggregation 3D cell culture |
| title | Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation |
| title_full | Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation |
| title_fullStr | Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation |
| title_full_unstemmed | Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation |
| title_short | Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation |
| title_sort | impact of source and manufacturing of collagen matrices on fibroblast cell growth and platelet aggregation |
| topic | collagen scaffolds fibroblasts platelet aggregation 3D cell culture |
| url | https://www.mdpi.com/1996-1944/10/9/1086 |
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