Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage
Qi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They can suppress growth of cancer cells by selecti...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01713-1 |
| _version_ | 1818420875020468224 |
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| author | Lei Qi Tonghe Pan Liling Ou Zhiqiang Ye Chunlei Yu Bijun Bao Zixia Wu Dayong Cao Liming Dai |
| author_facet | Lei Qi Tonghe Pan Liling Ou Zhiqiang Ye Chunlei Yu Bijun Bao Zixia Wu Dayong Cao Liming Dai |
| author_sort | Lei Qi |
| collection | DOAJ |
| description | Qi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They can suppress growth of cancer cells by selectively inducing DNA damage. |
| first_indexed | 2024-12-14T13:01:24Z |
| format | Article |
| id | doaj.art-b0a7ad99f02648159a7db7a588304692 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T13:01:24Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-b0a7ad99f02648159a7db7a5883046922022-12-21T23:00:26ZengNature PortfolioCommunications Biology2399-36422021-02-014111210.1038/s42003-021-01713-1Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damageLei Qi0Tonghe Pan1Liling Ou2Zhiqiang Ye3Chunlei Yu4Bijun Bao5Zixia Wu6Dayong Cao7Liming Dai8State key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityState key Laboratory of Ophthalmology, Optometry and Visual Science, Institute of Advanced Materials for Nano-Bio Applications, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical UniversityDepartment of General Surgery, The First Hospital of Qiqihar, Affiliated Qiqihar Hospital, Southern Medical UniversityAustralian Carbon Materials Centre (A-CMC), School of Chemical Engineering, University of New South WalesQi et al. develop nucleus targeting graphene quantum dots (GQDs) by modifying amine-functionalised GQDs with nucleus targeting TAT peptides. The resulting functionalised GQDs exhibit good biocompatibility, nucleus uptake, and cancer cell targeting. They can suppress growth of cancer cells by selectively inducing DNA damage.https://doi.org/10.1038/s42003-021-01713-1 |
| spellingShingle | Lei Qi Tonghe Pan Liling Ou Zhiqiang Ye Chunlei Yu Bijun Bao Zixia Wu Dayong Cao Liming Dai Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage Communications Biology |
| title | Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage |
| title_full | Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage |
| title_fullStr | Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage |
| title_full_unstemmed | Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage |
| title_short | Biocompatible nucleus-targeted graphene quantum dots for selective killing of cancer cells via DNA damage |
| title_sort | biocompatible nucleus targeted graphene quantum dots for selective killing of cancer cells via dna damage |
| url | https://doi.org/10.1038/s42003-021-01713-1 |
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