Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test
Anxiety disorder is one of the important public health problems. This study aimed to find out whether patchouli (Pogostemon cablin (Blanco) Benth.) essential oil (PEO) has an anxiolytic-like effect in mice. A total of 20 mice were divided into five treatment groups i.e. (C1) was treated with 1 mg/kg...
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| Format: | Article |
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Universitas Airlangga, Faculty of Veterinary Medicine
2023-12-01
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| Series: | Jurnal Medik Veteriner |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JMV/article/view/46205 |
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| author | Fadilla Anita Kinksky Johansyah Eka Pramyrtha Hestianah Rimayanti Rimayanti Nove Hidajati Kuncoro Puguh Santoso Sri Agus Sudjarwo Nanik Hidayatik |
| author_facet | Fadilla Anita Kinksky Johansyah Eka Pramyrtha Hestianah Rimayanti Rimayanti Nove Hidajati Kuncoro Puguh Santoso Sri Agus Sudjarwo Nanik Hidayatik |
| author_sort | Fadilla Anita Kinksky Johansyah |
| collection | DOAJ |
| description | Anxiety disorder is one of the important public health problems. This study aimed to find out whether patchouli (Pogostemon cablin (Blanco) Benth.) essential oil (PEO) has an anxiolytic-like effect in mice. A total of 20 mice were divided into five treatment groups i.e. (C1) was treated with 1 mg/kg of saline intraperitoneally; (C2) was treated with 1 mg/kg of diazepam intraperitoneally; (T1) 1% PEO inhalation, (T2) 2.5% PEO inhalation, and (T3) 5% PEO inhalation. All experimental animals were put in the Elevated Plus-Maze (EPM), observed for five minutes, and investigated the following parameters i.e. the total number of squares that are transverse in the open arms (STO), the number of visits to the open arms (VOA), the number of visits to the closed arms (VCA), the time spent in the open arms (TOA), and the time spent in the closed arms (TCA). In results, T1 and T2 groups had a minor impact on the VOA. T1 group also had little effect on TOA. Closed-arm activities (VCA and TCA) were unaffected by any of the treatments. The conclusion was revealed that T1 or less of PEO inhalation can potentially provide anxiolytic-like effects in mice. |
| first_indexed | 2024-03-08T17:18:08Z |
| format | Article |
| id | doaj.art-b0a7dd12eb8a47bd8125555bbb4c95f0 |
| institution | Directory Open Access Journal |
| issn | 2615-7497 2581-012X |
| language | English |
| last_indexed | 2024-03-08T17:18:08Z |
| publishDate | 2023-12-01 |
| publisher | Universitas Airlangga, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Jurnal Medik Veteriner |
| spelling | doaj.art-b0a7dd12eb8a47bd8125555bbb4c95f02024-01-03T10:07:32ZengUniversitas Airlangga, Faculty of Veterinary MedicineJurnal Medik Veteriner2615-74972581-012X2023-12-0163313610.20473/jmv.vol6.iss3.2023.31-3644291Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze TestFadilla Anita Kinksky Johansyah0https://orcid.org/0009-0009-4290-9478Eka Pramyrtha Hestianah1https://orcid.org/0000-0001-8679-040XRimayanti Rimayanti2https://orcid.org/0000-0002-6949-522XNove Hidajati3https://orcid.org/0000-0002-8769-5655Kuncoro Puguh Santoso4https://orcid.org/0000-0002-9561-1984Sri Agus Sudjarwo5https://orcid.org/0000-0002-7998-7500Nanik Hidayatik6https://orcid.org/0000-0002-7812-8368Bachelor Program of Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaDivision of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, SurabayaAnxiety disorder is one of the important public health problems. This study aimed to find out whether patchouli (Pogostemon cablin (Blanco) Benth.) essential oil (PEO) has an anxiolytic-like effect in mice. A total of 20 mice were divided into five treatment groups i.e. (C1) was treated with 1 mg/kg of saline intraperitoneally; (C2) was treated with 1 mg/kg of diazepam intraperitoneally; (T1) 1% PEO inhalation, (T2) 2.5% PEO inhalation, and (T3) 5% PEO inhalation. All experimental animals were put in the Elevated Plus-Maze (EPM), observed for five minutes, and investigated the following parameters i.e. the total number of squares that are transverse in the open arms (STO), the number of visits to the open arms (VOA), the number of visits to the closed arms (VCA), the time spent in the open arms (TOA), and the time spent in the closed arms (TCA). In results, T1 and T2 groups had a minor impact on the VOA. T1 group also had little effect on TOA. Closed-arm activities (VCA and TCA) were unaffected by any of the treatments. The conclusion was revealed that T1 or less of PEO inhalation can potentially provide anxiolytic-like effects in mice.https://e-journal.unair.ac.id/JMV/article/view/46205anxietyelevated plus-maze testessential oilpatchoulipublic health |
| spellingShingle | Fadilla Anita Kinksky Johansyah Eka Pramyrtha Hestianah Rimayanti Rimayanti Nove Hidajati Kuncoro Puguh Santoso Sri Agus Sudjarwo Nanik Hidayatik Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test Jurnal Medik Veteriner anxiety elevated plus-maze test essential oil patchouli public health |
| title | Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test |
| title_full | Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test |
| title_fullStr | Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test |
| title_full_unstemmed | Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test |
| title_short | Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test |
| title_sort | essential oil of patchouli inhalation exhibits an anxiolytic like effect in mice elevated plus maze test |
| topic | anxiety elevated plus-maze test essential oil patchouli public health |
| url | https://e-journal.unair.ac.id/JMV/article/view/46205 |
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