Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation
Abstract Metal oxide nanoparticles have emerged as exceptionally potent biomedical sensors and actuators due to their unique physicochemical features. Despite fascinating achievements, the current limited understanding of the molecular interplay between nanoparticles and the surrounding tissue remai...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202000912 |
| _version_ | 1818496318015799296 |
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| author | Martin T. Matter Jian‐Hao Li Ioana Lese Claudia Schreiner Laetitia Bernard Olivier Scholder Jasmin Hubeli Kerda Keevend Elena Tsolaki Enrico Bertero Sergio Bertazzo Robert Zboray Radu Olariu Mihai A. Constantinescu Renato Figi Inge K. Herrmann |
| author_facet | Martin T. Matter Jian‐Hao Li Ioana Lese Claudia Schreiner Laetitia Bernard Olivier Scholder Jasmin Hubeli Kerda Keevend Elena Tsolaki Enrico Bertero Sergio Bertazzo Robert Zboray Radu Olariu Mihai A. Constantinescu Renato Figi Inge K. Herrmann |
| author_sort | Martin T. Matter |
| collection | DOAJ |
| description | Abstract Metal oxide nanoparticles have emerged as exceptionally potent biomedical sensors and actuators due to their unique physicochemical features. Despite fascinating achievements, the current limited understanding of the molecular interplay between nanoparticles and the surrounding tissue remains a major obstacle in the rationalized development of nanomedicines, which is reflected in their poor clinical approval rate. This work reports on the nanoscopic characterization of inorganic nanoparticles in tissue by the example of complex metal oxide nanoparticle hybrids consisting of crystalline cerium oxide and the biodegradable ceramic bioglass. A validated analytical method based on semiquantitative X‐ray fluorescence and inductively coupled plasma spectrometry is used to assess nanoparticle biodistribution following intravenous and topical application. Then, a correlative multiscale analytical cascade based on a combination of microscopy and spectroscopy techniques shows that the topically applied hybrid nanoparticles remain at the initial site and are preferentially taken up into macrophages, form apatite on their surface, and lead to increased accumulation of lipids in their surroundings. Taken together, this work displays how modern analytical techniques can be harnessed to gain unprecedented insights into the biodistribution and biotransformation of complex inorganic nanoparticles. Such nanoscopic characterization is imperative for the rationalized engineering of safe and efficacious nanoparticle‐based systems. |
| first_indexed | 2024-12-10T18:31:48Z |
| format | Article |
| id | doaj.art-b0a9700b2670490c9d2f1755db5834f4 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-10T18:31:48Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-b0a9700b2670490c9d2f1755db5834f42022-12-22T01:37:55ZengWileyAdvanced Science2198-38442020-08-01715n/an/a10.1002/advs.202000912Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and BiotransformationMartin T. Matter0Jian‐Hao Li1Ioana Lese2Claudia Schreiner3Laetitia Bernard4Olivier Scholder5Jasmin Hubeli6Kerda Keevend7Elena Tsolaki8Enrico Bertero9Sergio Bertazzo10Robert Zboray11Radu Olariu12Mihai A. Constantinescu13Renato Figi14Inge K. Herrmann15Particles‐Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 SwitzerlandParticles‐Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 SwitzerlandDepartment of Plastic and Hand Surgery University Hospital Bern (Inselspital) University of Bern Bern 3010 SwitzerlandAdvanced Analytical Technologies Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 SwitzerlandNanoscale Materials Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 SwitzerlandNanoscale Materials Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 SwitzerlandAdvanced Analytical Technologies Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 SwitzerlandParticles‐Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 SwitzerlandParticles‐Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 SwitzerlandMechanics of Materials and Nanostructures Swiss Federal Laboratories for Materials Science and Technology (Empa) Feuerwerkerstrasse 39 Thun 3602 SwitzerlandDepartment of Medical Physics and Biomedical Engineering University College London (UCL) Malet Place Engineering Building London WC1E 6BT UKCenter for X‐ray Analytics Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 SwitzerlandDepartment of Plastic and Hand Surgery University Hospital Bern (Inselspital) University of Bern Bern 3010 SwitzerlandDepartment of Plastic and Hand Surgery University Hospital Bern (Inselspital) University of Bern Bern 3010 SwitzerlandAdvanced Analytical Technologies Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 SwitzerlandParticles‐Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 SwitzerlandAbstract Metal oxide nanoparticles have emerged as exceptionally potent biomedical sensors and actuators due to their unique physicochemical features. Despite fascinating achievements, the current limited understanding of the molecular interplay between nanoparticles and the surrounding tissue remains a major obstacle in the rationalized development of nanomedicines, which is reflected in their poor clinical approval rate. This work reports on the nanoscopic characterization of inorganic nanoparticles in tissue by the example of complex metal oxide nanoparticle hybrids consisting of crystalline cerium oxide and the biodegradable ceramic bioglass. A validated analytical method based on semiquantitative X‐ray fluorescence and inductively coupled plasma spectrometry is used to assess nanoparticle biodistribution following intravenous and topical application. Then, a correlative multiscale analytical cascade based on a combination of microscopy and spectroscopy techniques shows that the topically applied hybrid nanoparticles remain at the initial site and are preferentially taken up into macrophages, form apatite on their surface, and lead to increased accumulation of lipids in their surroundings. Taken together, this work displays how modern analytical techniques can be harnessed to gain unprecedented insights into the biodistribution and biotransformation of complex inorganic nanoparticles. Such nanoscopic characterization is imperative for the rationalized engineering of safe and efficacious nanoparticle‐based systems.https://doi.org/10.1002/advs.202000912analytical imagingbiological fatemultiscalenanosafetyspectral unmixing |
| spellingShingle | Martin T. Matter Jian‐Hao Li Ioana Lese Claudia Schreiner Laetitia Bernard Olivier Scholder Jasmin Hubeli Kerda Keevend Elena Tsolaki Enrico Bertero Sergio Bertazzo Robert Zboray Radu Olariu Mihai A. Constantinescu Renato Figi Inge K. Herrmann Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation Advanced Science analytical imaging biological fate multiscale nanosafety spectral unmixing |
| title | Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation |
| title_full | Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation |
| title_fullStr | Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation |
| title_full_unstemmed | Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation |
| title_short | Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation |
| title_sort | multiscale analysis of metal oxide nanoparticles in tissue insights into biodistribution and biotransformation |
| topic | analytical imaging biological fate multiscale nanosafety spectral unmixing |
| url | https://doi.org/10.1002/advs.202000912 |
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