Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis
Introduction: Proton pump inhibitors (PPIs) show a high level of efficacy and a high safety profile, and they have been increasingly prescribed in recent years. However, recent pharmacoepidemiological evidence has shown that PPI use has been associated with health risks and complications. Objectives...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423003365 |
| _version_ | 1797390567804502016 |
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| author | Aljoharah M. Algabbani Abdulaziz S. Alangari |
| author_facet | Aljoharah M. Algabbani Abdulaziz S. Alangari |
| author_sort | Aljoharah M. Algabbani |
| collection | DOAJ |
| description | Introduction: Proton pump inhibitors (PPIs) show a high level of efficacy and a high safety profile, and they have been increasingly prescribed in recent years. However, recent pharmacoepidemiological evidence has shown that PPI use has been associated with health risks and complications. Objectives: This study aimed to assess the prescribing patterns of proton pump inhibitors and the prevalence of potential drug–drug interactions (DDIs) among patients who use PPIs. Method: This was a retrospective analysis of electronic health records from the Ministry of National Guard Hospitals in Riyadh from January 2019 to June 2022. All adult patients who used PPIs were included to assess the prescribing patterns and drug utilization, including the number of prescriptions, duration of prescriptions, number of doses, and prescription indications. Potential DDIs were assessed based on concurrent use, which is defined as taking an interacting drug parallel to PPIs. The assessment includes complete or partial overlapping, with at least one day of overlapping. Results: The total number of PPI prescriptions was 80,365 for a total of 9,930 patients with a mean age of 67.5. The majority of PPIs were prescribed in high doses (74%), without reporting appropriate indications (95%), and 17% were prescribed for long-term use. A total of 24,575 (33.6%) potential DDIs with PPIs were found. Conclusion: The results showed that the majority of the PPI prescriptions were made with a high number of doses, without reporting appropriate indications, with some having potential DDIs. This might result in exposing patients to an increasing number of health risks. The findings highlight the importance of implementing a stewardship program for PPI prescription with periodic reassessments of patients’ needs for these medications. |
| first_indexed | 2024-03-08T23:13:43Z |
| format | Article |
| id | doaj.art-b0aa21c073f94181800789b29e71a5f7 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-08T23:13:43Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-b0aa21c073f94181800789b29e71a5f72023-12-15T07:22:55ZengElsevierSaudi Pharmaceutical Journal1319-01642023-12-013112101841Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysisAljoharah M. Algabbani0Abdulaziz S. Alangari1Department of Epidemiology and Biostatistics, College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia; Saudi Food and Drug Authority, Riyadh, Saudi Arabia; Corresponding authors at: King Saud bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi Arabia.Department of Epidemiology and Biostatistics, College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia; Corresponding authors at: King Saud bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi Arabia.Introduction: Proton pump inhibitors (PPIs) show a high level of efficacy and a high safety profile, and they have been increasingly prescribed in recent years. However, recent pharmacoepidemiological evidence has shown that PPI use has been associated with health risks and complications. Objectives: This study aimed to assess the prescribing patterns of proton pump inhibitors and the prevalence of potential drug–drug interactions (DDIs) among patients who use PPIs. Method: This was a retrospective analysis of electronic health records from the Ministry of National Guard Hospitals in Riyadh from January 2019 to June 2022. All adult patients who used PPIs were included to assess the prescribing patterns and drug utilization, including the number of prescriptions, duration of prescriptions, number of doses, and prescription indications. Potential DDIs were assessed based on concurrent use, which is defined as taking an interacting drug parallel to PPIs. The assessment includes complete or partial overlapping, with at least one day of overlapping. Results: The total number of PPI prescriptions was 80,365 for a total of 9,930 patients with a mean age of 67.5. The majority of PPIs were prescribed in high doses (74%), without reporting appropriate indications (95%), and 17% were prescribed for long-term use. A total of 24,575 (33.6%) potential DDIs with PPIs were found. Conclusion: The results showed that the majority of the PPI prescriptions were made with a high number of doses, without reporting appropriate indications, with some having potential DDIs. This might result in exposing patients to an increasing number of health risks. The findings highlight the importance of implementing a stewardship program for PPI prescription with periodic reassessments of patients’ needs for these medications.http://www.sciencedirect.com/science/article/pii/S1319016423003365PPIsDrug utilizationPatient safety |
| spellingShingle | Aljoharah M. Algabbani Abdulaziz S. Alangari Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis Saudi Pharmaceutical Journal PPIs Drug utilization Patient safety |
| title | Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis |
| title_full | Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis |
| title_fullStr | Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis |
| title_full_unstemmed | Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis |
| title_short | Proton pump inhibitor prescribing patterns and utilization: A retrospective chart review analysis |
| title_sort | proton pump inhibitor prescribing patterns and utilization a retrospective chart review analysis |
| topic | PPIs Drug utilization Patient safety |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423003365 |
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