Synthesis and biological evaluation of natural cyclic peptide
Only minute quantities of cyclopeptides obtained from natural resources restricted researchers to investigate their biological profile in detail, considering the wide spectrum of bioactivities associated with these natural compounds and in order to obtain a potent bioactive compound in good yield in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-12-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314724518300013 |
| _version_ | 1819315589224595456 |
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| author | Maya Sharma Indrajeet Singhvi Zainab Munawar Ali Manish Kumar Suresh Kumar Dev |
| author_facet | Maya Sharma Indrajeet Singhvi Zainab Munawar Ali Manish Kumar Suresh Kumar Dev |
| author_sort | Maya Sharma |
| collection | DOAJ |
| description | Only minute quantities of cyclopeptides obtained from natural resources restricted researchers to investigate their biological profile in detail, considering the wide spectrum of bioactivities associated with these natural compounds and in order to obtain a potent bioactive compound in good yield in a convenient and economical manner, an attempt has been made to synthesize cyclic peptides in the laboratory. In this study, it was of interest to synthesize a natural proline-rich Cyclic Hexapeptide Dichotomins J by coupling of tripeptide Boc- Ile-Phe-Leu-OH and Tyr-Ala Gly-OMe followed by cyclization of linear polypeptide fragment. Structure of synthesized cyclopeptide was confirmed by detailed spectral analysis including FTIR, 1H NMR, 13C NMR, MS and elemental analysis. From the results of biological evaluation, it was concluded that newly synthesized cyclopeptide possessed good antifungal, antimicrobial and anthelmintic activity. Keywords: Stellaria dichotoma, Dichotomins J, Cyclic hexapeptide, Peptide synthesis, Antimicrobial, Antifungal, Anthelmintic activity |
| first_indexed | 2024-12-24T10:02:30Z |
| format | Article |
| id | doaj.art-b0aae732211d4775989f8d8b95785188 |
| institution | Directory Open Access Journal |
| issn | 2314-7245 |
| language | English |
| last_indexed | 2024-12-24T10:02:30Z |
| publishDate | 2018-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b0aae732211d4775989f8d8b957851882022-12-21T17:01:00ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72452018-12-0142220228Synthesis and biological evaluation of natural cyclic peptideMaya Sharma0Indrajeet Singhvi1Zainab Munawar Ali2Manish Kumar3Suresh Kumar Dev4Pacific College of Pharmacy, Pratap Nagar, Airport Road, Udaipur, Rajasthan 313003, India; Corresponding author.Pacific College of Pharmacy, Pratap Nagar, Airport Road, Udaipur, Rajasthan 313003, IndiaPacific College of Pharmacy, Pratap Nagar, Airport Road, Udaipur, Rajasthan 313003, IndiaDepartment of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001, IndiaDepartment of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001, IndiaOnly minute quantities of cyclopeptides obtained from natural resources restricted researchers to investigate their biological profile in detail, considering the wide spectrum of bioactivities associated with these natural compounds and in order to obtain a potent bioactive compound in good yield in a convenient and economical manner, an attempt has been made to synthesize cyclic peptides in the laboratory. In this study, it was of interest to synthesize a natural proline-rich Cyclic Hexapeptide Dichotomins J by coupling of tripeptide Boc- Ile-Phe-Leu-OH and Tyr-Ala Gly-OMe followed by cyclization of linear polypeptide fragment. Structure of synthesized cyclopeptide was confirmed by detailed spectral analysis including FTIR, 1H NMR, 13C NMR, MS and elemental analysis. From the results of biological evaluation, it was concluded that newly synthesized cyclopeptide possessed good antifungal, antimicrobial and anthelmintic activity. Keywords: Stellaria dichotoma, Dichotomins J, Cyclic hexapeptide, Peptide synthesis, Antimicrobial, Antifungal, Anthelmintic activityhttp://www.sciencedirect.com/science/article/pii/S2314724518300013 |
| spellingShingle | Maya Sharma Indrajeet Singhvi Zainab Munawar Ali Manish Kumar Suresh Kumar Dev Synthesis and biological evaluation of natural cyclic peptide Future Journal of Pharmaceutical Sciences |
| title | Synthesis and biological evaluation of natural cyclic peptide |
| title_full | Synthesis and biological evaluation of natural cyclic peptide |
| title_fullStr | Synthesis and biological evaluation of natural cyclic peptide |
| title_full_unstemmed | Synthesis and biological evaluation of natural cyclic peptide |
| title_short | Synthesis and biological evaluation of natural cyclic peptide |
| title_sort | synthesis and biological evaluation of natural cyclic peptide |
| url | http://www.sciencedirect.com/science/article/pii/S2314724518300013 |
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