Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes
<b>AIM: </b>To assess the reproducibility of Cirrus high-definition optical coherence tomography (HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) for analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes <b>METHODS:</b> Forty-five eyes (one e...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2015-02-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325253/ |
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| author | Reza Soltani-Moghadam Yousef Alizadeh Ehsan Kazemnezhad Leili Mohamadreza Absari Haghighi |
| author_facet | Reza Soltani-Moghadam Yousef Alizadeh Ehsan Kazemnezhad Leili Mohamadreza Absari Haghighi |
| author_sort | Reza Soltani-Moghadam |
| collection | DOAJ |
| description | <b>AIM: </b>To assess the reproducibility of Cirrus high-definition optical coherence tomography (HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) for analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes
<b>METHODS:</b> Forty-five eyes (one eye from each glaucomatous patient) were imaged with Cirrus HD-OCT. Each eye was imaged three times by two separate operators. Intraclass correlation coefficient (ICC), coefficient of variation (CV), and test-retest variability were evaluated for both intraobserver and interobsever measurements
<b>RESULTS:</b> In intraobserver measurements, the average RNFL thickness ICC was 0.983. CV and test-retest variability were 2.3% and 4.4 µm respectively. In quadrants ICC ranged from 0.886 to 0.956, the lowest associated with nasal quadrant and CV ranged from 3.6% to 7.7%. In interobsever measurements, the average RNFL thickness ICC was 0.979. CV and test-retest variability were 2.4% and 4.5 µm respectively. In quadrants ICC ranged from 0.886 to 0.957, the lowest associated with nasal quadrant and CV ranged from 3.8% to 8.6%.
<b>CONCLUSION:</b> The reproducibility of Cirrus OCT for RNFL thickness is sufficiently good to be useful clinically as a measure of glaucoma progression. |
| first_indexed | 2024-04-13T00:57:53Z |
| format | Article |
| id | doaj.art-b0ab82c553d34f4b84b91f1a8c5f90df |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-13T00:57:53Z |
| publishDate | 2015-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-b0ab82c553d34f4b84b91f1a8c5f90df2022-12-22T03:09:36ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982015-02-018111311710.3980/j.issn.2222-3959.2015.01.21Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyesReza Soltani-Moghadam0Yousef Alizadeh1Ehsan Kazemnezhad Leili2Mohamadreza Absari Haghighi3Eye Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht 4139637459, Iran<br>Eye Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht 4139637459, Iran<br>Eye Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht 4139637459, Iran<br>Guilan University of Medical Sciences, Rasht 4139637459, Iran<b>AIM: </b>To assess the reproducibility of Cirrus high-definition optical coherence tomography (HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) for analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes <b>METHODS:</b> Forty-five eyes (one eye from each glaucomatous patient) were imaged with Cirrus HD-OCT. Each eye was imaged three times by two separate operators. Intraclass correlation coefficient (ICC), coefficient of variation (CV), and test-retest variability were evaluated for both intraobserver and interobsever measurements <b>RESULTS:</b> In intraobserver measurements, the average RNFL thickness ICC was 0.983. CV and test-retest variability were 2.3% and 4.4 µm respectively. In quadrants ICC ranged from 0.886 to 0.956, the lowest associated with nasal quadrant and CV ranged from 3.6% to 7.7%. In interobsever measurements, the average RNFL thickness ICC was 0.979. CV and test-retest variability were 2.4% and 4.5 µm respectively. In quadrants ICC ranged from 0.886 to 0.957, the lowest associated with nasal quadrant and CV ranged from 3.8% to 8.6%. <b>CONCLUSION:</b> The reproducibility of Cirrus OCT for RNFL thickness is sufficiently good to be useful clinically as a measure of glaucoma progression.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325253/optical coherence tomographyreproducibilityglaucomaretinal nerve fiber layerretinal nerve fiber layer |
| spellingShingle | Reza Soltani-Moghadam Yousef Alizadeh Ehsan Kazemnezhad Leili Mohamadreza Absari Haghighi Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes International Journal of Ophthalmology optical coherence tomography reproducibility glaucoma retinal nerve fiber layer retinal nerve fiber layer |
| title | Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes |
| title_full | Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes |
| title_fullStr | Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes |
| title_full_unstemmed | Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes |
| title_short | Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes |
| title_sort | reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus hd oct in glaucomatous eyes |
| topic | optical coherence tomography reproducibility glaucoma retinal nerve fiber layer retinal nerve fiber layer |
| url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325253/ |
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