Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-10-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/9/10/3307 |
_version_ | 1797550953573908480 |
---|---|
author | Jeremie D. Oliver Wasila Madhoun Emily M. Graham Russell Hendrycks Maranda Renouard Michael S. Hu |
author_facet | Jeremie D. Oliver Wasila Madhoun Emily M. Graham Russell Hendrycks Maranda Renouard Michael S. Hu |
author_sort | Jeremie D. Oliver |
collection | DOAJ |
description | The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive techniques have long been innovated in this field, there are crucial limitations to the surgical restoration of craniomaxillofacial form and function. Fortunately, the rise of regenerative medicine and surgery has expanded the possibilities for patients affected with hard and soft tissue deficits, allowing for the controlled engineering and regeneration of patient-specific defects. In particular, stem cell therapy has emerged in recent years as an adjuvant treatment for the targeted regeneration of craniomaxillofacial structures. This review outlines the current state of the art in stem cell therapies utilized for the engineered restoration and regeneration of skeletal defects in the craniofacial region. |
first_indexed | 2024-03-10T15:36:44Z |
format | Article |
id | doaj.art-b0adc7bcbc03462bb099aac6fb724e8b |
institution | Directory Open Access Journal |
issn | 2077-0383 |
language | English |
last_indexed | 2024-03-10T15:36:44Z |
publishDate | 2020-10-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Clinical Medicine |
spelling | doaj.art-b0adc7bcbc03462bb099aac6fb724e8b2023-11-20T17:09:44ZengMDPI AGJournal of Clinical Medicine2077-03832020-10-01910330710.3390/jcm9103307Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future DirectionsJeremie D. Oliver0Wasila Madhoun1Emily M. Graham2Russell Hendrycks3Maranda Renouard4Michael S. Hu5Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USAJoan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USASchool of Dentistry, School of Medicine, School of Pharmacy, University of Utah Health, Salt Lake City, UT 84112, USASchool of Dentistry, School of Medicine, School of Pharmacy, University of Utah Health, Salt Lake City, UT 84112, USASchool of Dentistry, School of Medicine, School of Pharmacy, University of Utah Health, Salt Lake City, UT 84112, USADepartment of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USAThe craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive techniques have long been innovated in this field, there are crucial limitations to the surgical restoration of craniomaxillofacial form and function. Fortunately, the rise of regenerative medicine and surgery has expanded the possibilities for patients affected with hard and soft tissue deficits, allowing for the controlled engineering and regeneration of patient-specific defects. In particular, stem cell therapy has emerged in recent years as an adjuvant treatment for the targeted regeneration of craniomaxillofacial structures. This review outlines the current state of the art in stem cell therapies utilized for the engineered restoration and regeneration of skeletal defects in the craniofacial region.https://www.mdpi.com/2077-0383/9/10/3307stem cellregenerative medicinetissue engineeringcraniofacialcleft palatebone |
spellingShingle | Jeremie D. Oliver Wasila Madhoun Emily M. Graham Russell Hendrycks Maranda Renouard Michael S. Hu Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions Journal of Clinical Medicine stem cell regenerative medicine tissue engineering craniofacial cleft palate bone |
title | Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions |
title_full | Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions |
title_fullStr | Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions |
title_full_unstemmed | Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions |
title_short | Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions |
title_sort | stem cells regenerating the craniofacial skeleton current state of the art and future directions |
topic | stem cell regenerative medicine tissue engineering craniofacial cleft palate bone |
url | https://www.mdpi.com/2077-0383/9/10/3307 |
work_keys_str_mv | AT jeremiedoliver stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections AT wasilamadhoun stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections AT emilymgraham stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections AT russellhendrycks stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections AT marandarenouard stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections AT michaelshu stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections |