Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions

The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive...

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Main Authors: Jeremie D. Oliver, Wasila Madhoun, Emily M. Graham, Russell Hendrycks, Maranda Renouard, Michael S. Hu
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/9/10/3307
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author Jeremie D. Oliver
Wasila Madhoun
Emily M. Graham
Russell Hendrycks
Maranda Renouard
Michael S. Hu
author_facet Jeremie D. Oliver
Wasila Madhoun
Emily M. Graham
Russell Hendrycks
Maranda Renouard
Michael S. Hu
author_sort Jeremie D. Oliver
collection DOAJ
description The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive techniques have long been innovated in this field, there are crucial limitations to the surgical restoration of craniomaxillofacial form and function. Fortunately, the rise of regenerative medicine and surgery has expanded the possibilities for patients affected with hard and soft tissue deficits, allowing for the controlled engineering and regeneration of patient-specific defects. In particular, stem cell therapy has emerged in recent years as an adjuvant treatment for the targeted regeneration of craniomaxillofacial structures. This review outlines the current state of the art in stem cell therapies utilized for the engineered restoration and regeneration of skeletal defects in the craniofacial region.
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spelling doaj.art-b0adc7bcbc03462bb099aac6fb724e8b2023-11-20T17:09:44ZengMDPI AGJournal of Clinical Medicine2077-03832020-10-01910330710.3390/jcm9103307Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future DirectionsJeremie D. Oliver0Wasila Madhoun1Emily M. Graham2Russell Hendrycks3Maranda Renouard4Michael S. Hu5Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USAJoan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USASchool of Dentistry, School of Medicine, School of Pharmacy, University of Utah Health, Salt Lake City, UT 84112, USASchool of Dentistry, School of Medicine, School of Pharmacy, University of Utah Health, Salt Lake City, UT 84112, USASchool of Dentistry, School of Medicine, School of Pharmacy, University of Utah Health, Salt Lake City, UT 84112, USADepartment of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USAThe craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive techniques have long been innovated in this field, there are crucial limitations to the surgical restoration of craniomaxillofacial form and function. Fortunately, the rise of regenerative medicine and surgery has expanded the possibilities for patients affected with hard and soft tissue deficits, allowing for the controlled engineering and regeneration of patient-specific defects. In particular, stem cell therapy has emerged in recent years as an adjuvant treatment for the targeted regeneration of craniomaxillofacial structures. This review outlines the current state of the art in stem cell therapies utilized for the engineered restoration and regeneration of skeletal defects in the craniofacial region.https://www.mdpi.com/2077-0383/9/10/3307stem cellregenerative medicinetissue engineeringcraniofacialcleft palatebone
spellingShingle Jeremie D. Oliver
Wasila Madhoun
Emily M. Graham
Russell Hendrycks
Maranda Renouard
Michael S. Hu
Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
Journal of Clinical Medicine
stem cell
regenerative medicine
tissue engineering
craniofacial
cleft palate
bone
title Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_full Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_fullStr Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_full_unstemmed Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_short Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_sort stem cells regenerating the craniofacial skeleton current state of the art and future directions
topic stem cell
regenerative medicine
tissue engineering
craniofacial
cleft palate
bone
url https://www.mdpi.com/2077-0383/9/10/3307
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AT emilymgraham stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections
AT russellhendrycks stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections
AT marandarenouard stemcellsregeneratingthecraniofacialskeletoncurrentstateoftheartandfuturedirections
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