Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease
The research was aimed at the investigation of systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease. We examined 42 patients with no clinical symptoms but at high risk of knee osteoarthrosis, and 12 donors with no musculoskeletal pathologies. It was establ...
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| Format: | Article |
| Language: | Russian |
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Private institution educational organization of higher education "Medical University "ReaViz"
2021-05-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
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| Online Access: | https://vestnik.reaviz.ru/jour/article/view/198 |
| _version_ | 1797697837179338752 |
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| author | S. V. Belova E. V. Gladkova R. A. Zubavlenko V. Yu. Ulyanov |
| author_facet | S. V. Belova E. V. Gladkova R. A. Zubavlenko V. Yu. Ulyanov |
| author_sort | S. V. Belova |
| collection | DOAJ |
| description | The research was aimed at the investigation of systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease. We examined 42 patients with no clinical symptoms but at high risk of knee osteoarthrosis, and 12 donors with no musculoskeletal pathologies. It was established that systemic abnormalities featured by the negative change in the cell immunity along with pro-inflammatory cytokine activation were detectable even in the early stage of primary osteoarthrosis. These had probably facilitated the progress of the immune response followed by the inflammatory reaction that led to the progress of destructive changes in the connective tissue structures of the knees4 the process was proven by the increase in cartilage oligomeric matrix protein as well as cartilage glycoprotein-39. |
| first_indexed | 2024-03-12T03:45:48Z |
| format | Article |
| id | doaj.art-b0adccf344374dcfb3c75a7371900077 |
| institution | Directory Open Access Journal |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| last_indexed | 2024-03-12T03:45:48Z |
| publishDate | 2021-05-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj.art-b0adccf344374dcfb3c75a73719000772023-09-03T12:58:04ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792021-05-0102717810.20340/vmirvz.2021.2.CLIN.5162Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the diseaseS. V. Belova0E. V. Gladkova1R. A. Zubavlenko2V. Yu. Ulyanov3Научно-исследовательский институт травматологии, ортопедии и нейрохирургии, Саратовский государственный медицинский университет им. В.И. РазумовскогоНаучно-исследовательский институт травматологии, ортопедии и нейрохирургии, Саратовский государственный медицинский университет им. В.И. РазумовскогоНаучно-исследовательский институт травматологии, ортопедии и нейрохирургии, Саратовский государственный медицинский университет им. В.И. РазумовскогоНаучно-исследовательский институт травматологии, ортопедии и нейрохирургии, Саратовский государственный медицинский университет им. В.И. РазумовскогоThe research was aimed at the investigation of systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease. We examined 42 patients with no clinical symptoms but at high risk of knee osteoarthrosis, and 12 donors with no musculoskeletal pathologies. It was established that systemic abnormalities featured by the negative change in the cell immunity along with pro-inflammatory cytokine activation were detectable even in the early stage of primary osteoarthrosis. These had probably facilitated the progress of the immune response followed by the inflammatory reaction that led to the progress of destructive changes in the connective tissue structures of the knees4 the process was proven by the increase in cartilage oligomeric matrix protein as well as cartilage glycoprotein-39.https://vestnik.reaviz.ru/jour/article/view/198первичный остеоартрозранняя стадияколенные суставысистемные проявления |
| spellingShingle | S. V. Belova E. V. Gladkova R. A. Zubavlenko V. Yu. Ulyanov Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье первичный остеоартроз ранняя стадия коленные суставы системные проявления |
| title | Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease |
| title_full | Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease |
| title_fullStr | Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease |
| title_full_unstemmed | Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease |
| title_short | Systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease |
| title_sort | systemic symptoms of primary knee osteoarthrosis in patients with the early stage of the disease |
| topic | первичный остеоартроз ранняя стадия коленные суставы системные проявления |
| url | https://vestnik.reaviz.ru/jour/article/view/198 |
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