Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults
Background and Objective Individuals have a unique circadian preference, which is based on differences in endogenous rhythm and environmental factors. There has been no study on the relationship between the morningness-eveningness (ME) preference and the polymorphisms of PER2 and CRY1 genes, which m...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Sleep Medicine
2015-12-01
|
| Series: | Sleep Medicine Research |
| Subjects: | |
| Online Access: | http://www.sleepmedres.org/upload/pdf/smr-6-2-60.pdf |
| _version_ | 1818931167649333248 |
|---|---|
| author | Jung Hie Lee Seong Jae Kim Se Yong Lee Jun-Won Hwang In Bum Suh |
| author_facet | Jung Hie Lee Seong Jae Kim Se Yong Lee Jun-Won Hwang In Bum Suh |
| author_sort | Jung Hie Lee |
| collection | DOAJ |
| description | Background and Objective Individuals have a unique circadian preference, which is based on differences in endogenous rhythm and environmental factors. There has been no study on the relationship between the morningness-eveningness (ME) preference and the polymorphisms of PER2 and CRY1 genes, which may play an essential role in the modulation of circadian rhythm. Our present study aims to examine the difference in the polymorphisms of PER2-2221A/G and CRY1-2790T/G, which are related to a greater cancer risk, according to the ME preference. Methods The Korean version of the Morningness-Eveningness Questionnaire was administered and buccal DNA samples were obtained from 425 Korean adults aged 18 years or older. We excluded subjects who were being treated for sleep disorders or those with shift work. 47 morning type (MT) (age: 44.57 ± 12.33, M:F = 14:33) subjects, 59 neither type (NT) (age: 35.20 ± 9.53, M:F = 20:39) subjects and 51 evening type (ET) (age: 28.80 ± 8.03, M:F = 14:37) subjects were finally included in the present study. The above candidate single nucleotide polymorphisms were analyzed by DNA sequencing or a SNaPshot assay. Results For the PER2-2221A/G and CRY1-2790T/G, there were no significant differences in the genotype distribution, allele frequency, or proportion of G allele positive subjects between the MT and ET groups. There was no significant difference in the mean scores of the MEQ-K, KESS, or PSQI between G allele positive and negative subjects for either PER2-A2221A/G or CRY1-2790T/G. Conclusions Our study did not support the association of the ME preference with the PER2-2221 A/G and CRY1-2790T/G in Korean adults. |
| first_indexed | 2024-12-20T04:12:17Z |
| format | Article |
| id | doaj.art-b0afb041474d454ea1fbbde076f32576 |
| institution | Directory Open Access Journal |
| issn | 2093-9175 2233-8853 |
| language | English |
| last_indexed | 2024-12-20T04:12:17Z |
| publishDate | 2015-12-01 |
| publisher | Korean Society of Sleep Medicine |
| record_format | Article |
| series | Sleep Medicine Research |
| spelling | doaj.art-b0afb041474d454ea1fbbde076f325762022-12-21T19:53:51ZengKorean Society of Sleep MedicineSleep Medicine Research2093-91752233-88532015-12-0162606510.17241/smr.2015.6.2.6068Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean AdultsJung Hie Lee0Seong Jae Kim1Se Yong Lee2Jun-Won Hwang3In Bum Suh4 Department of Psychiatry, Kangwon National University Hospital, Chuncheon, Korea Department of Psychiatry, Naeane Hospital, Wonju, Korea Department of Psychiatry, Kangwon National University Hospital, Chuncheon, Korea Department of Psychiatry, Kangwon National University Hospital, Chuncheon, Korea Department of Laboratory Medicine, Kangwon National University Hospital, Chuncheon, KoreaBackground and Objective Individuals have a unique circadian preference, which is based on differences in endogenous rhythm and environmental factors. There has been no study on the relationship between the morningness-eveningness (ME) preference and the polymorphisms of PER2 and CRY1 genes, which may play an essential role in the modulation of circadian rhythm. Our present study aims to examine the difference in the polymorphisms of PER2-2221A/G and CRY1-2790T/G, which are related to a greater cancer risk, according to the ME preference. Methods The Korean version of the Morningness-Eveningness Questionnaire was administered and buccal DNA samples were obtained from 425 Korean adults aged 18 years or older. We excluded subjects who were being treated for sleep disorders or those with shift work. 47 morning type (MT) (age: 44.57 ± 12.33, M:F = 14:33) subjects, 59 neither type (NT) (age: 35.20 ± 9.53, M:F = 20:39) subjects and 51 evening type (ET) (age: 28.80 ± 8.03, M:F = 14:37) subjects were finally included in the present study. The above candidate single nucleotide polymorphisms were analyzed by DNA sequencing or a SNaPshot assay. Results For the PER2-2221A/G and CRY1-2790T/G, there were no significant differences in the genotype distribution, allele frequency, or proportion of G allele positive subjects between the MT and ET groups. There was no significant difference in the mean scores of the MEQ-K, KESS, or PSQI between G allele positive and negative subjects for either PER2-A2221A/G or CRY1-2790T/G. Conclusions Our study did not support the association of the ME preference with the PER2-2221 A/G and CRY1-2790T/G in Korean adults.http://www.sleepmedres.org/upload/pdf/smr-6-2-60.pdfMorningness-eveningnessCancer riskPER2-2221A/GCRY1- 2790T/GKorean adults |
| spellingShingle | Jung Hie Lee Seong Jae Kim Se Yong Lee Jun-Won Hwang In Bum Suh Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults Sleep Medicine Research Morningness-eveningness Cancer risk PER2-2221A/G CRY1- 2790T/G Korean adults |
| title | Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults |
| title_full | Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults |
| title_fullStr | Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults |
| title_full_unstemmed | Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults |
| title_short | Association of PER2 and CRY1 Polymorphisms with the Morningness-Eveningness in Korean Adults |
| title_sort | association of per2 and cry1 polymorphisms with the morningness eveningness in korean adults |
| topic | Morningness-eveningness Cancer risk PER2-2221A/G CRY1- 2790T/G Korean adults |
| url | http://www.sleepmedres.org/upload/pdf/smr-6-2-60.pdf |
| work_keys_str_mv | AT junghielee associationofper2andcry1polymorphismswiththemorningnesseveningnessinkoreanadults AT seongjaekim associationofper2andcry1polymorphismswiththemorningnesseveningnessinkoreanadults AT seyonglee associationofper2andcry1polymorphismswiththemorningnesseveningnessinkoreanadults AT junwonhwang associationofper2andcry1polymorphismswiththemorningnesseveningnessinkoreanadults AT inbumsuh associationofper2andcry1polymorphismswiththemorningnesseveningnessinkoreanadults |