Genetic and Metabolite Variability in One-Carbon Metabolism Applied to an Insulin Resistance Model in Patients With Schizophrenia Receiving Atypical Antipsychotics

Genetic and Metabolite Variability in One-Carbon Metabolism Applied to an Insulin Resistance Model in Patients With Schizophrenia Receiving Atypical Antipsychotics

Background: Patients with schizophrenia are at high risk of pre-mature mortality due to cardiovascular disease (CVD). Our group has completed studies in pharmacogenomics and metabolomics that have independently identified perturbations in one-carbon metabolism as associated with risk factors for CVD...

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Bibliographic Details
Main Authors: Kristen M. Ward, Kyle Burghardt, A. Zarina Kraal, Andrew Jaeger, Larisa Yeomans, Cora McHugh, Alla Karnovsky, Kathleen A. Stringer, Vicki L. Ellingrod
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Psychiatry
Subjects:
pharmacogenomics
metabolomics
folate
one-carbon metabolism
cardiovascular disease
antipsychotics
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.623143/full

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