LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice

LncRNA-ZFAS1 Promotes Myocardial Ischemia-Reperfusion Injury Through DNA Methylation-Mediated Notch1 Down-Regulation in Mice

Summary: The most devastating and catastrophic deterioration of myocardial ischemia-reperfusion injury (MIRI) is cardiomyocyte death. Here we aimed to evaluate the role of lncRNA-ZFAS1 in MIRI and delineate its mechanism of action. The level of lncRNA-ZFAS1 was elevated in MIRI hearts, and artificia...

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Bibliographic Details
Main Authors: Mengmeng Li, BE, Lei Jiao, PhD, Yingchun Shao, BE, Haodong Li, BS, Lihua Sun, PhD, Qi Yu, MM, Manyu Gong, BE, Dongping Liu, BS, Yanying Wang, M.M, Lina Xuan, PhD, Xuewen Yang, MM, Yunmeng Qu, BS, Yaqi Wang, BS, Lintong Jiang, BS, Jingjing Han, BS, Ying Zhang, PhD, Yong Zhang, PhD
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:JACC: Basic to Translational Science
Subjects:
DNA methylation
long noncoding RNA
myocardial ischemia-reperfusion injury
Notch1
ZFAS1
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X22002236

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