Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior

Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior

Summary: Deletion of the obsessive-compulsive disorder (OCD)-associated gene SAP90/PSD-95-associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at corticostriatal synapses, causes OCD-like motor behaviors in mice. While corticostriatal synaptic dysfunction is central to this...

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Bibliographic Details
Main Authors: Jeffrey M. Malgady, Alexander Baez, Zachary B. Hobel, Kimberly Jimenez, Jack Goldfried, Eric M. Prager, Jennifer A. Wilking, Qiangge Zhang, Guoping Feng, Joshua L. Plotkin
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013967

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