A Novel Acetone Sensor for Body Fluids
Ketones are well-known biomarkers of fat oxidation produced in the liver as a result of lipolysis. These biomarkers include acetoacetic acid and β-hydroxybutyric acid in the blood/urine and acetone in our breath and skin. Monitoring ketone production in the body is essential for people who use calor...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/14/1/4 |
| _version_ | 1827372623703572480 |
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| author | Oscar Osorio Perez Ngan Anh Nguyen Asher Hendricks Shaun Victor Sabrina Jimena Mora Nanxi Yu Xiaojun Xian Shaopeng Wang Doina Kulick Erica Forzani |
| author_facet | Oscar Osorio Perez Ngan Anh Nguyen Asher Hendricks Shaun Victor Sabrina Jimena Mora Nanxi Yu Xiaojun Xian Shaopeng Wang Doina Kulick Erica Forzani |
| author_sort | Oscar Osorio Perez |
| collection | DOAJ |
| description | Ketones are well-known biomarkers of fat oxidation produced in the liver as a result of lipolysis. These biomarkers include acetoacetic acid and β-hydroxybutyric acid in the blood/urine and acetone in our breath and skin. Monitoring ketone production in the body is essential for people who use caloric intake deficit to reduce body weight or use ketogenic diets for wellness or therapeutic treatments. Current methods to monitor ketones include urine dipsticks, capillary blood monitors, and breath analyzers. However, these existing methods have certain disadvantages that preclude them from being used more widely. In this work, we introduce a novel acetone sensor device that can detect acetone levels in breath and overcome the drawbacks of existing sensing approaches. The critical element of the device is a robust sensor with the capability to measure acetone using a complementary metal oxide semiconductor (CMOS) chip and convenient data analysis from a red, green, and blue deconvolution imaging approach. The acetone sensor device demonstrated sensitivity of detection in the micromolar-concentration range, selectivity for detection of acetone in breath, and a lifetime stability of at least one month. The sensor device utility was probed with real tests on breath samples using an established blood ketone reference method. |
| first_indexed | 2024-03-08T11:04:39Z |
| format | Article |
| id | doaj.art-b0b3e541d8e2473884454f70e7d27103 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-08T11:04:39Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-b0b3e541d8e2473884454f70e7d271032024-01-26T15:22:45ZengMDPI AGBiosensors2079-63742023-12-01141410.3390/bios14010004A Novel Acetone Sensor for Body FluidsOscar Osorio Perez0Ngan Anh Nguyen1Asher Hendricks2Shaun Victor3Sabrina Jimena Mora4Nanxi Yu5Xiaojun Xian6Shaopeng Wang7Doina Kulick8Erica Forzani9School of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USASchool of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USASchool of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USACenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USACenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USACenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USACenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USACenter for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, 1001 S McAllister Ave., Tempe, AZ 85281, USAMayo Clinic, Scottsdale, AZ 85289, USASchool of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USAKetones are well-known biomarkers of fat oxidation produced in the liver as a result of lipolysis. These biomarkers include acetoacetic acid and β-hydroxybutyric acid in the blood/urine and acetone in our breath and skin. Monitoring ketone production in the body is essential for people who use caloric intake deficit to reduce body weight or use ketogenic diets for wellness or therapeutic treatments. Current methods to monitor ketones include urine dipsticks, capillary blood monitors, and breath analyzers. However, these existing methods have certain disadvantages that preclude them from being used more widely. In this work, we introduce a novel acetone sensor device that can detect acetone levels in breath and overcome the drawbacks of existing sensing approaches. The critical element of the device is a robust sensor with the capability to measure acetone using a complementary metal oxide semiconductor (CMOS) chip and convenient data analysis from a red, green, and blue deconvolution imaging approach. The acetone sensor device demonstrated sensitivity of detection in the micromolar-concentration range, selectivity for detection of acetone in breath, and a lifetime stability of at least one month. The sensor device utility was probed with real tests on breath samples using an established blood ketone reference method.https://www.mdpi.com/2079-6374/14/1/4wearable sensorpoint of caremetabolic ratefat oxidationfat burningketones |
| spellingShingle | Oscar Osorio Perez Ngan Anh Nguyen Asher Hendricks Shaun Victor Sabrina Jimena Mora Nanxi Yu Xiaojun Xian Shaopeng Wang Doina Kulick Erica Forzani A Novel Acetone Sensor for Body Fluids Biosensors wearable sensor point of care metabolic rate fat oxidation fat burning ketones |
| title | A Novel Acetone Sensor for Body Fluids |
| title_full | A Novel Acetone Sensor for Body Fluids |
| title_fullStr | A Novel Acetone Sensor for Body Fluids |
| title_full_unstemmed | A Novel Acetone Sensor for Body Fluids |
| title_short | A Novel Acetone Sensor for Body Fluids |
| title_sort | novel acetone sensor for body fluids |
| topic | wearable sensor point of care metabolic rate fat oxidation fat burning ketones |
| url | https://www.mdpi.com/2079-6374/14/1/4 |
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