Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension

Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a clinical condition characterized by pulmonary arterial remodeling and vasoconstriction, which promote chronic vessel obstruction and elevation of pulmonary vascular resistance. Long-term right ventricular (RV) overload leads to RV dysfunction and failure, w...

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Bibliographic Details
Main Authors: Allan K. N. Alencar, Guilherme C. Montes, Eliezer J. Barreiro, Roberto T. Sudo, Gisele Zapata-Sudo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary arterial hypertension
cardiopulmonary system
adenosine receptors
cell proliferation
right ventricle dysfunction
pleiotropic effects
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00858/full

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