Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus

Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus

Secondary infections with Streptococcus pneumoniae cause severe pneumonia and enhance lethality during influenza epidemics and pandemics. Structural and functional similarities with viral neuraminidase (NA) suggest that the highly prevalent pneumococcal NAs, NanA and NanB, might contribute to this l...

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Bibliographic Details
Main Authors: Elisabeth eWalther, Zhongli eXu, Martina eRichter, Johannes eKirchmair, Ulrike eGrienke, Judith Maria Rollinger, Andi eKrumbholz, Hans Peter eSaluz, Wolfgang ePfister, Andreas eSauerbrei, Michaela eSchmidtke
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Microbiology
Subjects:
Antibacterial
microbial communication
antiviral
enzyme inhibition
pandemic influenza
Pneumococci
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00357/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00357/full

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