Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer
Breast cancer is the most commonly occurring cancer in women and the fifth leading cause of global cancer mortality. MicroRNAs (miRNAs) are essential regulators in the oncogenesis process and the identification of tumor-specific circulating miRNAs could be used for early detection of cancer. We aime...
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| Format: | Article |
| Language: | English |
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Ain Shams University
2021-12-01
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| Series: | Archives of Pharmaceutical Sciences Ain Shams University |
| Subjects: | |
| Online Access: | https://aps.journals.ekb.eg/article_211579.html |
| _version_ | 1818442259444531200 |
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| author | Sherihan AbdelHamid Hany AbdelAziz Amany Kamal |
| author_facet | Sherihan AbdelHamid Hany AbdelAziz Amany Kamal |
| author_sort | Sherihan AbdelHamid |
| collection | DOAJ |
| description | Breast cancer is the most commonly occurring cancer in women and the fifth leading cause of global cancer mortality. MicroRNAs (miRNAs) are essential regulators in the oncogenesis process and the identification of tumor-specific circulating miRNAs could be used for early detection of cancer. We aimed to investigate the expression pattern of microRNA 96 (miR-96) and explore its diagnostic potential in breast cancer.
Subjects and methods: This study comprised 30 treatment-naïve female patients diagnosed with primary breast cancer and 20 healthy volunteers as the control group. MicroRNA 96 (miR-96) expression was measured in serum samples using Reverse Transcription Quantitative polymerase chain reaction. The diagnostic value of miR-96 was analyzed with Receiver-operating characteristics (ROC) curve.
Results: Our results shows that miR-96 was significantly upregulated in breast cancer cases compared to control subjects (P<0.05). MiR-96 showed a significant diagnostic clinical value with area under the curve (AUC) 0.959, 100% sensitivity and 95.2% specificity.
Conclusion: The current study implies that serum miR-96 may be a valuable and promising diagnostic marker for early detection of breast cancer. Future studies are needed to investigate the potential role of miR-96 in predicting prognosis and monitoring response to treatment. Additionally, further research is required to study the feasibility of silencing miR-96 using antagomirs for the management of breast cancer. |
| first_indexed | 2024-12-14T18:41:18Z |
| format | Article |
| id | doaj.art-b0bc025b1e884e4ba08124231a2009bf |
| institution | Directory Open Access Journal |
| issn | 2356-8380 2356-8399 |
| language | English |
| last_indexed | 2024-12-14T18:41:18Z |
| publishDate | 2021-12-01 |
| publisher | Ain Shams University |
| record_format | Article |
| series | Archives of Pharmaceutical Sciences Ain Shams University |
| spelling | doaj.art-b0bc025b1e884e4ba08124231a2009bf2022-12-21T22:51:29ZengAin Shams UniversityArchives of Pharmaceutical Sciences Ain Shams University2356-83802356-83992021-12-01522042011https://dx.doi.org/10.21608/aps.2021.83850.1064Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast CancerSherihan AbdelHamid0Hany AbdelAziz1Amany Kamal2Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptDepartment of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo 11591, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptBreast cancer is the most commonly occurring cancer in women and the fifth leading cause of global cancer mortality. MicroRNAs (miRNAs) are essential regulators in the oncogenesis process and the identification of tumor-specific circulating miRNAs could be used for early detection of cancer. We aimed to investigate the expression pattern of microRNA 96 (miR-96) and explore its diagnostic potential in breast cancer. Subjects and methods: This study comprised 30 treatment-naïve female patients diagnosed with primary breast cancer and 20 healthy volunteers as the control group. MicroRNA 96 (miR-96) expression was measured in serum samples using Reverse Transcription Quantitative polymerase chain reaction. The diagnostic value of miR-96 was analyzed with Receiver-operating characteristics (ROC) curve. Results: Our results shows that miR-96 was significantly upregulated in breast cancer cases compared to control subjects (P<0.05). MiR-96 showed a significant diagnostic clinical value with area under the curve (AUC) 0.959, 100% sensitivity and 95.2% specificity. Conclusion: The current study implies that serum miR-96 may be a valuable and promising diagnostic marker for early detection of breast cancer. Future studies are needed to investigate the potential role of miR-96 in predicting prognosis and monitoring response to treatment. Additionally, further research is required to study the feasibility of silencing miR-96 using antagomirs for the management of breast cancer.https://aps.journals.ekb.eg/article_211579.htmlmicrornasmir-96breast cancerdiagnosisliquid biopsy |
| spellingShingle | Sherihan AbdelHamid Hany AbdelAziz Amany Kamal Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer Archives of Pharmaceutical Sciences Ain Shams University micrornas mir-96 breast cancer diagnosis liquid biopsy |
| title | Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer |
| title_full | Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer |
| title_fullStr | Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer |
| title_full_unstemmed | Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer |
| title_short | Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer |
| title_sort | serum microrna 96 as a potential diagnostic marker in breast cancer |
| topic | micrornas mir-96 breast cancer diagnosis liquid biopsy |
| url | https://aps.journals.ekb.eg/article_211579.html |
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