DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways

DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways

Doxorubicin (DOX) is a very potent and effective anticancer agent. However, the effectiveness of DOX in osteosarcoma is usually limited by the acquired drug resistance. Recently, Vitamin D (Vit-D) was shown to suppress the growth of many human cancer cells. Taken together, we synthesized DOX-Vit D b...

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Bibliographic Details
Main Authors: Zaid H. Maayah, Ti Zhang, Marcus Laird Forrest, Samaa Alrushaid, Michael R. Doschak, Neal M. Davies, Ayman O. S. El-Kadi
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Pharmaceutics
Subjects:
doxorubicin
MG63
Vitamin D
DOX-Vit D
Online Access:http://www.mdpi.com/1999-4923/10/3/144

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