Perspective insights into hydrogels and nanomaterials for ischemic stroke
Ischemic stroke (IS) is a neurological disorder prevalent worldwide with a high disability and mortality rate. In the clinic setting, tissue plasminogen activator (tPA) and thrombectomy could restore blood flow of the occlusion region and improve the outcomes of IS patients; however, these therapies...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.1058753/full |
| _version_ | 1828055987532070912 |
|---|---|
| author | Qingbo Yu Qingbo Yu Zhang Jian Dan Yang Tao Zhu |
| author_facet | Qingbo Yu Qingbo Yu Zhang Jian Dan Yang Tao Zhu |
| author_sort | Qingbo Yu |
| collection | DOAJ |
| description | Ischemic stroke (IS) is a neurological disorder prevalent worldwide with a high disability and mortality rate. In the clinic setting, tissue plasminogen activator (tPA) and thrombectomy could restore blood flow of the occlusion region and improve the outcomes of IS patients; however, these therapies are restricted by a narrow time window. Although several preclinical trials have revealed the molecular and cellular mechanisms underlying infarct lesions, the translatability of most findings is unsatisfactory, which contributes to the emergence of new biomaterials, such as hydrogels and nanomaterials, for the treatment of IS. Biomaterials function as structural scaffolds or are combined with other compounds to release therapeutic drugs. Biomaterial-mediated drug delivery approaches could optimize the therapeutic effects based on their brain-targeting property, biocompatibility, and functionality. This review summarizes the advances in biomaterials in the last several years, aiming to discuss the therapeutic potential of new biomaterials from the bench to bedside. The promising prospects of new biomaterials indicate the possibility of an organic combination between materialogy and medicine, which is a novel field under exploration. |
| first_indexed | 2024-04-10T20:48:19Z |
| format | Article |
| id | doaj.art-b0bca5619c5545999c5bced7b5e8e15e |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-10T20:48:19Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-b0bca5619c5545999c5bced7b5e8e15e2023-01-24T05:31:42ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-01-011610.3389/fncel.2022.10587531058753Perspective insights into hydrogels and nanomaterials for ischemic strokeQingbo Yu0Qingbo Yu1Zhang Jian2Dan Yang3Tao Zhu4Laboratory of Anesthesia & Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, North Sichuan Medical College, Nanchong, ChinaSichuan Provincial Maternity and Child Health Care Hospital, Women’s and Children’s Hospital Affiliated of Chengdu Medical College, Chengdu, ChinaDepartment of Anesthesiology, North Sichuan Medical College, Nanchong, ChinaLaboratory of Anesthesia & Critical Care Medicine, Department of Anesthesiology, Translational Neuroscience Center, West China Hospital of Sichuan University, Chengdu, ChinaIschemic stroke (IS) is a neurological disorder prevalent worldwide with a high disability and mortality rate. In the clinic setting, tissue plasminogen activator (tPA) and thrombectomy could restore blood flow of the occlusion region and improve the outcomes of IS patients; however, these therapies are restricted by a narrow time window. Although several preclinical trials have revealed the molecular and cellular mechanisms underlying infarct lesions, the translatability of most findings is unsatisfactory, which contributes to the emergence of new biomaterials, such as hydrogels and nanomaterials, for the treatment of IS. Biomaterials function as structural scaffolds or are combined with other compounds to release therapeutic drugs. Biomaterial-mediated drug delivery approaches could optimize the therapeutic effects based on their brain-targeting property, biocompatibility, and functionality. This review summarizes the advances in biomaterials in the last several years, aiming to discuss the therapeutic potential of new biomaterials from the bench to bedside. The promising prospects of new biomaterials indicate the possibility of an organic combination between materialogy and medicine, which is a novel field under exploration.https://www.frontiersin.org/articles/10.3389/fncel.2022.1058753/fullstrokebiomaterialshydrogelsnanoparticlesneuroprotectionneurorestoration |
| spellingShingle | Qingbo Yu Qingbo Yu Zhang Jian Dan Yang Tao Zhu Perspective insights into hydrogels and nanomaterials for ischemic stroke Frontiers in Cellular Neuroscience stroke biomaterials hydrogels nanoparticles neuroprotection neurorestoration |
| title | Perspective insights into hydrogels and nanomaterials for ischemic stroke |
| title_full | Perspective insights into hydrogels and nanomaterials for ischemic stroke |
| title_fullStr | Perspective insights into hydrogels and nanomaterials for ischemic stroke |
| title_full_unstemmed | Perspective insights into hydrogels and nanomaterials for ischemic stroke |
| title_short | Perspective insights into hydrogels and nanomaterials for ischemic stroke |
| title_sort | perspective insights into hydrogels and nanomaterials for ischemic stroke |
| topic | stroke biomaterials hydrogels nanoparticles neuroprotection neurorestoration |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.1058753/full |
| work_keys_str_mv | AT qingboyu perspectiveinsightsintohydrogelsandnanomaterialsforischemicstroke AT qingboyu perspectiveinsightsintohydrogelsandnanomaterialsforischemicstroke AT zhangjian perspectiveinsightsintohydrogelsandnanomaterialsforischemicstroke AT danyang perspectiveinsightsintohydrogelsandnanomaterialsforischemicstroke AT taozhu perspectiveinsightsintohydrogelsandnanomaterialsforischemicstroke |