Role of the cystathionine β-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome

Role of the cystathionine β-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome

Background: Overexpression of the transsulfuration enzyme cystathionine-β-synthase (CBS), and overproduction of its product, hydrogen sulfide (H2S) are recognized as potential pathogenetic factors in Down syndrome (DS). The purpose of the study was to determine how the mitochondrial function and cor...

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Bibliographic Details
Main Authors: Theodora Panagaki, Laszlo Pecze, Elisa B. Randi, Anni I. Nieminen, Csaba Szabo
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
Down syndrome
Metabolism
Oxidative phosphorylation
Glycolysis
Hydrogen sulfide
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001884

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http://www.sciencedirect.com/science/article/pii/S2213231722001884

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