Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes
Mitochondria are surrounded by two membranes; the outer mitochondrial membrane and the inner mitochondrial membrane. They are unique organelles since they have their own DNA, the mitochondrial DNA (mtDNA), which is replicated continuously. Mitochondrial membranes have direct interaction with mtDNA a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0375/12/6/625 |
| _version_ | 1797484495000043520 |
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| author | Mohammed Almannai Azza Salah Ayman W. El-Hattab |
| author_facet | Mohammed Almannai Azza Salah Ayman W. El-Hattab |
| author_sort | Mohammed Almannai |
| collection | DOAJ |
| description | Mitochondria are surrounded by two membranes; the outer mitochondrial membrane and the inner mitochondrial membrane. They are unique organelles since they have their own DNA, the mitochondrial DNA (mtDNA), which is replicated continuously. Mitochondrial membranes have direct interaction with mtDNA and are therefore involved in organization of the mitochondrial genome. They also play essential roles in mitochondrial dynamics and the supply of nucleotides for mtDNA synthesis. In this review, we will discuss how the mitochondrial membranes interact with mtDNA and how this interaction is essential for mtDNA maintenance. We will review different mtDNA maintenance disorders that result from defects in this crucial interaction. Finally, we will review therapeutic approaches relevant to defects in mitochondrial membranes. |
| first_indexed | 2024-03-09T23:05:11Z |
| format | Article |
| id | doaj.art-b0c002bc66704a0c8e0e1dd53a4ed024 |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T23:05:11Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-b0c002bc66704a0c8e0e1dd53a4ed0242023-11-23T17:55:01ZengMDPI AGMembranes2077-03752022-06-0112662510.3390/membranes12060625Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical SyndromesMohammed Almannai0Azza Salah1Ayman W. El-Hattab2Genetics and Precision Medicine Department, King Abdullah Specialized Children Hospital, Riyadh P.O. Box 22490, Saudi ArabiaDepartment of Pediatrics, University Hospital Sharjah, Sharjah P.O. Box 72772, United Arab EmiratesDepartment of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab EmiratesMitochondria are surrounded by two membranes; the outer mitochondrial membrane and the inner mitochondrial membrane. They are unique organelles since they have their own DNA, the mitochondrial DNA (mtDNA), which is replicated continuously. Mitochondrial membranes have direct interaction with mtDNA and are therefore involved in organization of the mitochondrial genome. They also play essential roles in mitochondrial dynamics and the supply of nucleotides for mtDNA synthesis. In this review, we will discuss how the mitochondrial membranes interact with mtDNA and how this interaction is essential for mtDNA maintenance. We will review different mtDNA maintenance disorders that result from defects in this crucial interaction. Finally, we will review therapeutic approaches relevant to defects in mitochondrial membranes.https://www.mdpi.com/2077-0375/12/6/625mitochondriaIMMOMMfissionfusionmtDNA |
| spellingShingle | Mohammed Almannai Azza Salah Ayman W. El-Hattab Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes Membranes mitochondria IMM OMM fission fusion mtDNA |
| title | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
| title_full | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
| title_fullStr | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
| title_full_unstemmed | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
| title_short | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
| title_sort | mitochondrial membranes and mitochondrial genome interactions and clinical syndromes |
| topic | mitochondria IMM OMM fission fusion mtDNA |
| url | https://www.mdpi.com/2077-0375/12/6/625 |
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