Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function
In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=4;spage=694;epage=699;aulast=Qin |
| _version_ | 1828838769863688192 |
|---|---|
| author | Lu Qin Jianhua Li |
| author_facet | Lu Qin Jianhua Li |
| author_sort | Lu Qin |
| collection | DOAJ |
| description | In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed by intermittent claudication. The limb ischemia also amplifies autonomic responses during exercise. In the process of pain and autonomic responses originating exercising muscle, a number of receptors in afferent nerves sense ischemic changes and send signals to the central nervous system leading to autonomic responses. This review integrates recent study results in terms of perspectives including how nerve growth factor affects muscle sensory nerve receptors in peripheral artery disease and thereby alters responses of sympathetic nerve activity and blood pressure to active muscle. For the sensory nerve receptors, we emphasize the role played by transient receptor potential vanilloid type 1, purinergic P2X purinoceptor 3 and acid sensing ion channel subtype 3 in amplified sympathetic nerve activity responses in peripheral artery disease. |
| first_indexed | 2024-12-12T19:09:45Z |
| format | Article |
| id | doaj.art-b0c044b1957a4f3aa847aefdfd65e2d4 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-12T19:09:45Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-b0c044b1957a4f3aa847aefdfd65e2d42022-12-22T00:14:53ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-0116469469910.4103/1673-5374.293132Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic functionLu QinJianhua LiIn peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs. The painful perception is induced and exaggerate during walking, and is relieved by rest. This symptom is termed by intermittent claudication. The limb ischemia also amplifies autonomic responses during exercise. In the process of pain and autonomic responses originating exercising muscle, a number of receptors in afferent nerves sense ischemic changes and send signals to the central nervous system leading to autonomic responses. This review integrates recent study results in terms of perspectives including how nerve growth factor affects muscle sensory nerve receptors in peripheral artery disease and thereby alters responses of sympathetic nerve activity and blood pressure to active muscle. For the sensory nerve receptors, we emphasize the role played by transient receptor potential vanilloid type 1, purinergic P2X purinoceptor 3 and acid sensing ion channel subtype 3 in amplified sympathetic nerve activity responses in peripheral artery disease.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=4;spage=694;epage=699;aulast=Qinacid sensing ion channel subtype 3; exercise pressor reflex; muscle afferents; nerve growth factor; p2x purinoceptor 3; peripheral artery disease; transient receptor potential vanilloid type 1 |
| spellingShingle | Lu Qin Jianhua Li Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function Neural Regeneration Research acid sensing ion channel subtype 3; exercise pressor reflex; muscle afferents; nerve growth factor; p2x purinoceptor 3; peripheral artery disease; transient receptor potential vanilloid type 1 |
| title | Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function |
| title_full | Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function |
| title_fullStr | Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function |
| title_full_unstemmed | Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function |
| title_short | Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function |
| title_sort | nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function |
| topic | acid sensing ion channel subtype 3; exercise pressor reflex; muscle afferents; nerve growth factor; p2x purinoceptor 3; peripheral artery disease; transient receptor potential vanilloid type 1 |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=4;spage=694;epage=699;aulast=Qin |
| work_keys_str_mv | AT luqin nervegrowthfactorinmuscleafferentneuronsofperipheralarterydiseaseandautonomicfunction AT jianhuali nervegrowthfactorinmuscleafferentneuronsofperipheralarterydiseaseandautonomicfunction |