Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial
Abstract Background Many patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV1 when they do sports or during exercise-challenge. It has been described that long-chain polyunsaturated fatty acids (LCPUFA) could exert a protecti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-020-01343-2 |
| _version_ | 1828869463672356864 |
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| author | M. Dreßler D. Fussbroich L. Böhler E. Herrmann N. Benker M. Tytyk J. Schulze R. Schubert C. Beermann S. Zielen |
| author_facet | M. Dreßler D. Fussbroich L. Böhler E. Herrmann N. Benker M. Tytyk J. Schulze R. Schubert C. Beermann S. Zielen |
| author_sort | M. Dreßler |
| collection | DOAJ |
| description | Abstract Background Many patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV1 when they do sports or during exercise-challenge. It has been described that long-chain polyunsaturated fatty acids (LCPUFA) could exert a protective effect on EIA. Methods In this study the protective effect of supplementation with a special combination of n-3 and n-6 LCPUFA (sc-LCPUFA) (total 1.19 g/ day) were investigated in an EIA cold air provocation model. Primary outcome measure: Decrease in FEV1 after exercise challenge and secondary outcome measure: anti-inflammatory effects monitored by exhaled NO (eNO) before and after sc-LCPUFA supplementation versus placebo. Results Ninety-nine patients with exercise-induced symptoms aged 10 to 45 were screened by a standardized exercise challenge in a cold air chamber at 4 °C. Seventy-three patients fulfilled the inclusion criteria of a FEV1 decrease > 15% and were treated double-blind placebo-controlled for 4 weeks either with sc-LCPUFA or placebo. Thirty-two patients in each group completed the study. Mean FEV1 decrease after cold air exercise challenge and eNO were unchanged after 4 weeks sc-LCPUFA supplementation. Conclusion Supplementation with sc-LCPUFA at a dose of 1.19 g/d did not have any broncho-protective and anti-inflammatory effects on EIA. Trial registration Clinical trial registration number: NCT02410096. Registered 7 February 2015 at Clinicaltrial.gov |
| first_indexed | 2024-12-13T05:49:54Z |
| format | Article |
| id | doaj.art-b0c0e6da070b42c2acb911ed71842467 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-13T05:49:54Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-b0c0e6da070b42c2acb911ed718424672022-12-21T23:57:34ZengBMCLipids in Health and Disease1476-511X2020-07-0119111010.1186/s12944-020-01343-2Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trialM. Dreßler0D. Fussbroich1L. Böhler2E. Herrmann3N. Benker4M. Tytyk5J. Schulze6R. Schubert7C. Beermann8S. Zielen9Department for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-UniversityDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-UniversityDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-UniversityInstitute of Biostatistics and Mathematical Modelling, Goethe-UniversityDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-UniversityDepartment of Food Technology, University of Applied ScienceDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-UniversityDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-UniversityDepartment of Food Technology, University of Applied ScienceDepartment for Children and Adolescents, Division of Allergology, Pulmonology and Cystic fibrosis, Goethe-UniversityAbstract Background Many patients suffering from exercise-induced asthma (EIA) have normal lung function at rest and show symptoms and a decline in FEV1 when they do sports or during exercise-challenge. It has been described that long-chain polyunsaturated fatty acids (LCPUFA) could exert a protective effect on EIA. Methods In this study the protective effect of supplementation with a special combination of n-3 and n-6 LCPUFA (sc-LCPUFA) (total 1.19 g/ day) were investigated in an EIA cold air provocation model. Primary outcome measure: Decrease in FEV1 after exercise challenge and secondary outcome measure: anti-inflammatory effects monitored by exhaled NO (eNO) before and after sc-LCPUFA supplementation versus placebo. Results Ninety-nine patients with exercise-induced symptoms aged 10 to 45 were screened by a standardized exercise challenge in a cold air chamber at 4 °C. Seventy-three patients fulfilled the inclusion criteria of a FEV1 decrease > 15% and were treated double-blind placebo-controlled for 4 weeks either with sc-LCPUFA or placebo. Thirty-two patients in each group completed the study. Mean FEV1 decrease after cold air exercise challenge and eNO were unchanged after 4 weeks sc-LCPUFA supplementation. Conclusion Supplementation with sc-LCPUFA at a dose of 1.19 g/d did not have any broncho-protective and anti-inflammatory effects on EIA. Trial registration Clinical trial registration number: NCT02410096. Registered 7 February 2015 at Clinicaltrial.govhttp://link.springer.com/article/10.1186/s12944-020-01343-2Exercise-induced asthmaExercise challengeForced expiratory volume in 1 sExhaled nitric oxideLong-chain polyunsaturated fatty acidsDouble-blind placebo-controlled trial |
| spellingShingle | M. Dreßler D. Fussbroich L. Böhler E. Herrmann N. Benker M. Tytyk J. Schulze R. Schubert C. Beermann S. Zielen Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial Lipids in Health and Disease Exercise-induced asthma Exercise challenge Forced expiratory volume in 1 s Exhaled nitric oxide Long-chain polyunsaturated fatty acids Double-blind placebo-controlled trial |
| title | Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial |
| title_full | Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial |
| title_fullStr | Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial |
| title_full_unstemmed | Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial |
| title_short | Oil supplementation with a special combination of n-3 and n-6 long-chain polyunsaturated fatty acids does not protect for exercise induced asthma: a double-blind placebo-controlled trial |
| title_sort | oil supplementation with a special combination of n 3 and n 6 long chain polyunsaturated fatty acids does not protect for exercise induced asthma a double blind placebo controlled trial |
| topic | Exercise-induced asthma Exercise challenge Forced expiratory volume in 1 s Exhaled nitric oxide Long-chain polyunsaturated fatty acids Double-blind placebo-controlled trial |
| url | http://link.springer.com/article/10.1186/s12944-020-01343-2 |
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