Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition

Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition

Background: Hepatocellular carcinoma (HCC) represents a major health burden with limited curative treatment options. There is a substantial unmet need to develop innovative approaches to impact the progression of advanced HCC. Haprolid is a novel natural component isolated from myxobacteria. Haproli...

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Bibliographic Details
Main Authors: Jun Xing, Vikas Bhuria, Khac Cuong Bui, Mai Ly Thi Nguyen, Zexi Hu, Chih-Jen Hsieh, Kathrin Wittstein, Marc Stadler, Ludwig Wilkens, Jun Li, Markus Kalesse, Przemyslaw Bozko, Ruben R. Plentz
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
hcc
haprolid
rb/e2f
akt/mtor
emt
cell cycle
apoptosis
Online Access:https://www.mdpi.com/2072-6694/12/3/615

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