Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD
Roland Buhl,1 Donald Banerji21Pulmonary Department, Mainz University Hospital, Mainz, Germany; 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, USAAbstract: Bronchodilators are central in the symptomatic management of chronic obstructive pulmonary disease (COPD). Long-acting muscarinic antag...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2012-10-01
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| Series: | International Journal of COPD |
| Online Access: | http://www.dovepress.com/profile-of-glycopyrronium-for-once-daily-treatment-of-moderate-to-seve-a11367 |
| _version_ | 1811310253414809600 |
|---|---|
| author | Buhl R Banerji D |
| author_facet | Buhl R Banerji D |
| author_sort | Buhl R |
| collection | DOAJ |
| description | Roland Buhl,1 Donald Banerji21Pulmonary Department, Mainz University Hospital, Mainz, Germany; 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, USAAbstract: Bronchodilators are central in the symptomatic management of chronic obstructive pulmonary disease (COPD). Long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) are the main classes of long-acting bronchodilators. To date, tiotropium is the only once-daily LAMA available for the treatment of COPD. Glycopyrronium is a novel LAMA, currently in development for COPD. Phase II studies have shown that glycopyrronium 50 µg once daily provides clinically significant 24-hour bronchodilation with a rapid onset of action, which is faster than that of tiotropium, and a favorable safety and tolerability profile. The Phase III GLycopyrronium bromide in COPD airWays (GLOW) program has now confirmed the long-term efficacy and tolerability of glycopyrronium 50 µg once daily. The three studies included in this program have further shown that the effect of glycopyrronium versus placebo is similar to that of tiotropium in reducing dyspnea and the risk of exacerbations, as well as improving lung function, exercise tolerance, and health status in patients with COPD. The safety profile of glycopyrronium is also similar to that of tiotropium in terms of overall incidence of adverse events and muscarinic side effects. Glycopyrronium could be an alternative choice to tiotropium, and like tiotropium, has the potential to be used as a monotherapy or combination therapy. Phase II studies have shown that a fixed-dose combination of glycopyrronium and the 24-hour LABA indacaterol, produces rapid and sustained bronchodilation compared with indacaterol monotherapy in patients with COPD. Phase III studies are currently ongoing to assess the long-term efficacy and safety of this combination.Keywords: NVA237, glycopyrronium, chronic obstructive pulmonary disease, once daily, muscarinic antagonist |
| first_indexed | 2024-04-13T09:55:54Z |
| format | Article |
| id | doaj.art-b0c2ecff4d944f45bddd8ff7baf1d541 |
| institution | Directory Open Access Journal |
| issn | 1176-9106 1178-2005 |
| language | English |
| last_indexed | 2024-04-13T09:55:54Z |
| publishDate | 2012-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-b0c2ecff4d944f45bddd8ff7baf1d5412022-12-22T02:51:25ZengDove Medical PressInternational Journal of COPD1176-91061178-20052012-10-012012default729741Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPDBuhl RBanerji DRoland Buhl,1 Donald Banerji21Pulmonary Department, Mainz University Hospital, Mainz, Germany; 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, USAAbstract: Bronchodilators are central in the symptomatic management of chronic obstructive pulmonary disease (COPD). Long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) are the main classes of long-acting bronchodilators. To date, tiotropium is the only once-daily LAMA available for the treatment of COPD. Glycopyrronium is a novel LAMA, currently in development for COPD. Phase II studies have shown that glycopyrronium 50 µg once daily provides clinically significant 24-hour bronchodilation with a rapid onset of action, which is faster than that of tiotropium, and a favorable safety and tolerability profile. The Phase III GLycopyrronium bromide in COPD airWays (GLOW) program has now confirmed the long-term efficacy and tolerability of glycopyrronium 50 µg once daily. The three studies included in this program have further shown that the effect of glycopyrronium versus placebo is similar to that of tiotropium in reducing dyspnea and the risk of exacerbations, as well as improving lung function, exercise tolerance, and health status in patients with COPD. The safety profile of glycopyrronium is also similar to that of tiotropium in terms of overall incidence of adverse events and muscarinic side effects. Glycopyrronium could be an alternative choice to tiotropium, and like tiotropium, has the potential to be used as a monotherapy or combination therapy. Phase II studies have shown that a fixed-dose combination of glycopyrronium and the 24-hour LABA indacaterol, produces rapid and sustained bronchodilation compared with indacaterol monotherapy in patients with COPD. Phase III studies are currently ongoing to assess the long-term efficacy and safety of this combination.Keywords: NVA237, glycopyrronium, chronic obstructive pulmonary disease, once daily, muscarinic antagonisthttp://www.dovepress.com/profile-of-glycopyrronium-for-once-daily-treatment-of-moderate-to-seve-a11367 |
| spellingShingle | Buhl R Banerji D Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD International Journal of COPD |
| title | Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD |
| title_full | Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD |
| title_fullStr | Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD |
| title_full_unstemmed | Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD |
| title_short | Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD |
| title_sort | profile of glycopyrronium for once daily treatment of moderate to severe copd |
| url | http://www.dovepress.com/profile-of-glycopyrronium-for-once-daily-treatment-of-moderate-to-seve-a11367 |
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