Different induction therapy protocols experience based on depleting antibodies for kidney transplantation
Aim. To analyze the efficacy and safety of different induction therapy protocols experience based on depleting antibodies for kidney transplantation (ATGAM, Timoglobulin).Material and methods. The study included 107 non-sensitized patients who underwent primary kidney allotransplantation in the peri...
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2016-02-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/42 |
| _version_ | 1797759275016126464 |
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| author | S. V. Arzumanov D. V. Tiptsov A. E. Mitish A. K. Gramotnev |
| author_facet | S. V. Arzumanov D. V. Tiptsov A. E. Mitish A. K. Gramotnev |
| author_sort | S. V. Arzumanov |
| collection | DOAJ |
| description | Aim. To analyze the efficacy and safety of different induction therapy protocols experience based on depleting antibodies for kidney transplantation (ATGAM, Timoglobulin).Material and methods. The study included 107 non-sensitized patients who underwent primary kidney allotransplantation in the period from January 2012 to March 2014. Patients were divided into 3 groups according to the ongoing induction immunosuppressive therapy. Group I, patients receiving the drug ATGAM (n = 67). Group II – Timoglobulin (n = 30). Group III, patients received a combination of the introduction of basiliximab and ATGAM (n = 10). All patients received basic triple immunosuppressive therapy: tacrolimus, mycophenolic acid, methylprednisolone tapering.Results. The incidence of acute rejection in group I – 7,5% , in group II – 0%, in group III – 0% (p = 0,15). The incidence of severe thrombocytopenia in group I – 2,7%, in group II – 0% (p < 0,05), in group III – 10%. Incidence of CMV viremia in group I – 6,16%, in group II – 6,6%, in the group III – 10%, respectively (p > 0,05). In the 2-nd and 3-rd group registered one case of CMV pneumonia in the early postoperative period.Conclusion. Use of exhaustible polyclonal antibodies as drugs of choice for renal transplantation induction therapy in primary unsensitized patients is warranted. Further research is needed for evaluation of 5- and 10-year results. |
| first_indexed | 2024-03-12T18:42:04Z |
| format | Article |
| id | doaj.art-b0c4ea4daf9243ebb94069c751e81918 |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2024-03-12T18:42:04Z |
| publishDate | 2016-02-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-b0c4ea4daf9243ebb94069c751e819182023-08-02T07:48:49ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092016-02-0102141942Different induction therapy protocols experience based on depleting antibodies for kidney transplantationS. V. Arzumanov0D. V. Tiptsov1A. E. Mitish2A. K. Gramotnev3НИИ урологии и интервенционной радиологии им. Н.А. Лопаткина – филиал ГБУ «Национальный медицинский радиологический центр» МЗ РФНИИ урологии и интервенционной радиологии им. Н.А. Лопаткина – филиал ГБУ «Национальный медицинский радиологический центр» МЗ РФНИИ урологии и интервенционной радиологии им. Н.А. Лопаткина – филиал ГБУ «Национальный медицинский радиологический центр» МЗ РФНИИ урологии и интервенционной радиологии им. Н.А. Лопаткина – филиал ГБУ «Национальный медицинский радиологический центр» МЗ РФAim. To analyze the efficacy and safety of different induction therapy protocols experience based on depleting antibodies for kidney transplantation (ATGAM, Timoglobulin).Material and methods. The study included 107 non-sensitized patients who underwent primary kidney allotransplantation in the period from January 2012 to March 2014. Patients were divided into 3 groups according to the ongoing induction immunosuppressive therapy. Group I, patients receiving the drug ATGAM (n = 67). Group II – Timoglobulin (n = 30). Group III, patients received a combination of the introduction of basiliximab and ATGAM (n = 10). All patients received basic triple immunosuppressive therapy: tacrolimus, mycophenolic acid, methylprednisolone tapering.Results. The incidence of acute rejection in group I – 7,5% , in group II – 0%, in group III – 0% (p = 0,15). The incidence of severe thrombocytopenia in group I – 2,7%, in group II – 0% (p < 0,05), in group III – 10%. Incidence of CMV viremia in group I – 6,16%, in group II – 6,6%, in the group III – 10%, respectively (p > 0,05). In the 2-nd and 3-rd group registered one case of CMV pneumonia in the early postoperative period.Conclusion. Use of exhaustible polyclonal antibodies as drugs of choice for renal transplantation induction therapy in primary unsensitized patients is warranted. Further research is needed for evaluation of 5- and 10-year results.https://www.jtransplantologiya.ru/jour/article/view/42лимфоцитоистощающие антителаострое отторжениеиндукционная терапияцитомегаловирус |
| spellingShingle | S. V. Arzumanov D. V. Tiptsov A. E. Mitish A. K. Gramotnev Different induction therapy protocols experience based on depleting antibodies for kidney transplantation Трансплантология (Москва) лимфоцитоистощающие антитела острое отторжение индукционная терапия цитомегаловирус |
| title | Different induction therapy protocols experience based on depleting antibodies for kidney transplantation |
| title_full | Different induction therapy protocols experience based on depleting antibodies for kidney transplantation |
| title_fullStr | Different induction therapy protocols experience based on depleting antibodies for kidney transplantation |
| title_full_unstemmed | Different induction therapy protocols experience based on depleting antibodies for kidney transplantation |
| title_short | Different induction therapy protocols experience based on depleting antibodies for kidney transplantation |
| title_sort | different induction therapy protocols experience based on depleting antibodies for kidney transplantation |
| topic | лимфоцитоистощающие антитела острое отторжение индукционная терапия цитомегаловирус |
| url | https://www.jtransplantologiya.ru/jour/article/view/42 |
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