Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
Pamela KushnerUniversity of California, Irvine College of Medicine, California, USAAbstract: Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-04-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Online Access: | http://www.dovepress.com/minimizing-the-risk-of-hypoglycemia-in-patients-with-type-2-diabetes-m-a4232 |
| _version_ | 1797936629228240896 |
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| author | Pamela Kushner |
| author_facet | Pamela Kushner |
| author_sort | Pamela Kushner |
| collection | DOAJ |
| description | Pamela KushnerUniversity of California, Irvine College of Medicine, California, USAAbstract: Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2 diabetes mellitus (T2DM). Chronically recurrent hypoglycemia may lead to an impairment of the counterregulatory system, with the potential for the development of hypoglycemia unawareness syndrome, increased severe hypoglycemia-associated hospitalization, and increased mortality. Hypoglycemic events may also have negative implications in cardiovascular disease and/or dementia. Avoidance of hypoglycemia by treating with appropriate, individualized regimens for patients with T2DM should be a primary focus of physicians. Utilizing traditional agents (eg, metformin and thiazolidinediones) that do not promote hypoglycemia, in combination with newer agents such as dipeptidyl peptidase-4 inhibitors and incretin mimetics, could offer a therapeutic advantage when trying to help patients reach their hemoglobin A1c goal without the added risk of hypoglycemia.Keywords: hypoglycemia, type 2 diabetes mellitus, incretin, dipeptidyl peptidase-4 inhibitors, diabetes management |
| first_indexed | 2024-04-10T18:32:18Z |
| format | Article |
| id | doaj.art-b0c502d246c044ddaf6ada5c4b0b8245 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:32:18Z |
| publishDate | 2010-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-b0c502d246c044ddaf6ada5c4b0b82452023-02-02T03:18:40ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072010-04-012010default4953Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitusPamela KushnerPamela KushnerUniversity of California, Irvine College of Medicine, California, USAAbstract: Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2 diabetes mellitus (T2DM). Chronically recurrent hypoglycemia may lead to an impairment of the counterregulatory system, with the potential for the development of hypoglycemia unawareness syndrome, increased severe hypoglycemia-associated hospitalization, and increased mortality. Hypoglycemic events may also have negative implications in cardiovascular disease and/or dementia. Avoidance of hypoglycemia by treating with appropriate, individualized regimens for patients with T2DM should be a primary focus of physicians. Utilizing traditional agents (eg, metformin and thiazolidinediones) that do not promote hypoglycemia, in combination with newer agents such as dipeptidyl peptidase-4 inhibitors and incretin mimetics, could offer a therapeutic advantage when trying to help patients reach their hemoglobin A1c goal without the added risk of hypoglycemia.Keywords: hypoglycemia, type 2 diabetes mellitus, incretin, dipeptidyl peptidase-4 inhibitors, diabetes managementhttp://www.dovepress.com/minimizing-the-risk-of-hypoglycemia-in-patients-with-type-2-diabetes-m-a4232 |
| spellingShingle | Pamela Kushner Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus Diabetes, Metabolic Syndrome and Obesity |
| title | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
| title_full | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
| title_fullStr | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
| title_short | Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
| title_sort | minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus |
| url | http://www.dovepress.com/minimizing-the-risk-of-hypoglycemia-in-patients-with-type-2-diabetes-m-a4232 |
| work_keys_str_mv | AT pamelakushner minimizingtheriskofhypoglycemiainpatientswithtype2diabetesmellitus |