The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults
Carbohydrate antigen 19-9 (CA 19-9) is a commonly used tumor marker for pancreatic cancer. However, CA 19-9 can be overexpressed in several benign inflammatory diseases. We investigated the relationship between high CA 19-9 level and low muscle mass (LMM) in healthy adults without cancer. Participan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/15/3394 |
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| author | Jae Hyun Lee Dong-Kun Kim Mi-Yeon Lee Han-Sol Lim Min-Jung Kwon Yong-Taek Lee Kyung Jae Yoon Chul-Hyun Park |
| author_facet | Jae Hyun Lee Dong-Kun Kim Mi-Yeon Lee Han-Sol Lim Min-Jung Kwon Yong-Taek Lee Kyung Jae Yoon Chul-Hyun Park |
| author_sort | Jae Hyun Lee |
| collection | DOAJ |
| description | Carbohydrate antigen 19-9 (CA 19-9) is a commonly used tumor marker for pancreatic cancer. However, CA 19-9 can be overexpressed in several benign inflammatory diseases. We investigated the relationship between high CA 19-9 level and low muscle mass (LMM) in healthy adults without cancer. Participants who underwent evaluation of muscle mass and CA 19-9 were included. Exclusion criteria were any malignancy, cardiovascular disease, tuberculosis, and chronic lung/liver disease. Participants were classified into “normal”, “mild LMM”, and “severe LMM” groups based on the skeletal muscle mass index. Multivariable logistic regression analyses were conducted to assess the association of high CA 19-9 with muscle mass status. A total of 263,061 adults were included. The mean age and SMI were 41.03 years and 7.13 kg/m<sup>2</sup>. After adjustments for various confounders, high CA 19-9 was independently associated with mild LMM (adjusted odds ratio, 1.677 [95% confidence interval, 1.533–1.834]) and severe LMM (2.651 [2.126–3.306]) compared to the normal group. Furthermore, the association between high CA 19-9 and severe LMM was stronger in men than in women. Elevated CA 19-9 levels were independently associated with a higher prevalence of LMM in healthy adults without cancer. Therefore, increased CA 19-9 could be utilized as a novel biomarker for sarcopenia. |
| first_indexed | 2024-03-11T00:19:48Z |
| format | Article |
| id | doaj.art-b0c60111c16f4623acbc83c7df703768 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:19:48Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-b0c60111c16f4623acbc83c7df7037682023-11-18T23:23:56ZengMDPI AGNutrients2072-66432023-07-011515339410.3390/nu15153394The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy AdultsJae Hyun Lee0Dong-Kun Kim1Mi-Yeon Lee2Han-Sol Lim3Min-Jung Kwon4Yong-Taek Lee5Kyung Jae Yoon6Chul-Hyun Park7Department of Rehabilitation Medicine, Kosin University College of Medicine, Busan 49267, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of KoreaDivision of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of KoreaDepartment of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of KoreaDepartment of Physical and Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Republic of KoreaCarbohydrate antigen 19-9 (CA 19-9) is a commonly used tumor marker for pancreatic cancer. However, CA 19-9 can be overexpressed in several benign inflammatory diseases. We investigated the relationship between high CA 19-9 level and low muscle mass (LMM) in healthy adults without cancer. Participants who underwent evaluation of muscle mass and CA 19-9 were included. Exclusion criteria were any malignancy, cardiovascular disease, tuberculosis, and chronic lung/liver disease. Participants were classified into “normal”, “mild LMM”, and “severe LMM” groups based on the skeletal muscle mass index. Multivariable logistic regression analyses were conducted to assess the association of high CA 19-9 with muscle mass status. A total of 263,061 adults were included. The mean age and SMI were 41.03 years and 7.13 kg/m<sup>2</sup>. After adjustments for various confounders, high CA 19-9 was independently associated with mild LMM (adjusted odds ratio, 1.677 [95% confidence interval, 1.533–1.834]) and severe LMM (2.651 [2.126–3.306]) compared to the normal group. Furthermore, the association between high CA 19-9 and severe LMM was stronger in men than in women. Elevated CA 19-9 levels were independently associated with a higher prevalence of LMM in healthy adults without cancer. Therefore, increased CA 19-9 could be utilized as a novel biomarker for sarcopenia.https://www.mdpi.com/2072-6643/15/15/3394carbohydrate antigen 19-9skeletal muscle masspopulation study |
| spellingShingle | Jae Hyun Lee Dong-Kun Kim Mi-Yeon Lee Han-Sol Lim Min-Jung Kwon Yong-Taek Lee Kyung Jae Yoon Chul-Hyun Park The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults Nutrients carbohydrate antigen 19-9 skeletal muscle mass population study |
| title | The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults |
| title_full | The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults |
| title_fullStr | The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults |
| title_full_unstemmed | The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults |
| title_short | The Association of Carbohydrate Antigen (CA) 19-9 Levels and Low Skeletal Muscle Mass in Healthy Adults |
| title_sort | association of carbohydrate antigen ca 19 9 levels and low skeletal muscle mass in healthy adults |
| topic | carbohydrate antigen 19-9 skeletal muscle mass population study |
| url | https://www.mdpi.com/2072-6643/15/15/3394 |
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