Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart

Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart

Cell therapy has been a promising strategy for cardiac repair after myocardial infarction (MI), but a poor ischemic environment and low cell delivery efficiency remain significant challenges. The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI, but it...

Full description

Bibliographic Details
Main Authors:	Ge Guan, Da Huo, Yanzhao Li, Xiaolin Zhao, Yinghao Li, Zhongliang Qin, Dayu Sun, Guanyuan Yang, Mingcan Yang, Ju Tan, Wen Zeng, Chuhong Zhu
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2021-12-01
Series:	Bioactive Materials
Subjects:	Stem cell-laden splenic hydrogel hiPSC differentiation platform Antioxidant stress Myocardial infarction Cardiac repair
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X21001766

Similar Items

Optical Mapping in hiPSC-CM and Zebrafish to Resolve Cardiac Arrhythmias
by: Bert Vandendriessche, et al.
Published: (2020-12-01)

hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery
by: Junjun Li, et al.
Published: (2020-11-01)

Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts
by: Madalena Carido, et al.
Published: (2023-10-01)

Modeling Movement Disorders via Generation of hiPSC-Derived Motor Neurons
by: Masuma Akter, et al.
Published: (2022-11-01)

An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm
by: Akwasi D. Akwaboah, et al.
Published: (2021-06-01)

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates
by: Suzan J. G. Knottnerus, et al.
Published: (2020-04-01)

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte modelling of cardiovascular diseases for natural compound discovery
by: Keyang Zhu, et al.
Published: (2023-01-01)

hiPSC-derived GRN-deficient astrocytes delay spiking activity of developing neurons
by: Christopher Lee, et al.
Published: (2023-06-01)

hiPSC-Derived Schwann Cells Influence Myogenic Differentiation in Neuromuscular Cocultures
by: Sarah Janice Hörner, et al.
Published: (2021-11-01)

The three-dimensionality of the hiPSC-CM spheroid contributes to the variability of the field potential
by: Minki Hwang, et al.
Published: (2023-03-01)

hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation
by: Cláudia C. Miranda, et al.
Published: (2020-07-01)

Integrated Manufacturing of Suspended and Aligned Nanofibrous Scaffold for Structural Maturation and Synchronous Contraction of HiPSC-Derived Cardiomyocytes
by: Lingling Liu, et al.
Published: (2023-06-01)

Isogenic hiPSC-derived liver-on-chip platforms: A valuable tool for modeling metabolic liver diseases
by: Kehinde Oluwasegun Aina
Published: (2023-12-01)

Expression of Extracellular Vesicle PIWI-Interacting RNAs Throughout hiPSC-Cardiomyocyte Differentiation
by: Ana F. Louro, et al.
Published: (2022-06-01)

From bedside to the bench: patient-specific hiPSC-EC models uncover endothelial dysfunction in genetic cardiomyopathies
by: Martina Rabino, et al.
Published: (2023-07-01)

Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts
by: Charles M. Kerr, et al.
Published: (2024-01-01)

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls
by: Swagata Ghatak, et al.
Published: (2019-11-01)

Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures
by: Ari Ogaki, et al.
Published: (2022-07-01)

Challenges in Physiological Phenotyping of hiPSC-Derived Neurons: From 2D Cultures to 3D Brain Organoids
by: Pedro Mateos-Aparicio, et al.
Published: (2020-08-01)

Does Enhanced Structural Maturity of hiPSC-Cardiomyocytes Better for the Detection of Drug-Induced Cardiotoxicity?
by: Dieter Van de Sande, et al.
Published: (2023-04-01)

Generation of hiPSC-Derived Skeletal Muscle Cells: Exploiting the Potential of Skeletal Muscle-Derived hiPSCs
by: Eric Metzler, et al.
Published: (2022-05-01)

Characterizing the secretome of licensed hiPSC-derived MSCs
by: Yolande F. M. Ramos, et al.
Published: (2022-09-01)

Hydrogel‐Sheathed hiPSC‐Derived Heart Microtissue Enables Anchor‐Free Contractile Force Measurement
by: Yuta Kurashina, et al.
Published: (2023-12-01)

Merits of hiPSC-Derived Cardiomyocytes for In Vitro Research and Testing Drug Toxicity
by: Ping-Hsien Wang, et al.
Published: (2022-10-01)

Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
by: Louise Delsing, et al.
Published: (2019-08-01)

Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
by: Francesco Lodola, et al.
Published: (2021-07-01)

Preclinical Large Animal Porcine Models for Cardiac Regeneration and Its Clinical Translation: Role of hiPSC-Derived Cardiomyocytes
by: Divya Sridharan, et al.
Published: (2023-04-01)

Quantitative proteomic and phosphoproteomic analysis reveal the relationship between mitochondrial dysfunction and cytoskeletal remodeling in hiPSC-CMs deficient in PINK1
by: Huiwen Liu, et al.
Published: (2023-08-01)

Toward a Microencapsulated 3D hiPSC-Derived in vitro Cardiac Microtissue for Recapitulation of Human Heart Microenvironment Features
by: Bernardo Abecasis, et al.
Published: (2020-11-01)

SARS-CoV-2-infected hiPSC-derived cardiomyocytes reveal dynamic changes in the COVID-19 hearts
by: Xiao Li, et al.
Published: (2023-12-01)

Decoding HiPSC-CM’s Response to SARS-CoV-2: mapping the molecular landscape of cardiac injury
by: Sicheng Chen, et al.
Published: (2024-03-01)

Differentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy
by: Wei Zheng, et al.
Published: (2018-08-01)

Altered action potential waveform and shorter axonal initial segment in hiPSC-derived motor neurons with mutations in VRK1
by: Rémi Bos, et al.
Published: (2022-03-01)

Evaluation of chronic drug-induced electrophysiological and cytotoxic effects using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
by: C. Altrocchi, et al.
Published: (2023-07-01)

Applying hiPSCs and Biomaterials Towards an Understanding and Treatment of Traumatic Brain Injury
by: María Lacalle-Aurioles, et al.
Published: (2020-11-01)

Generation of an hiPSC-Derived Co-Culture System to Assess the Effects of Neuroinflammation on Blood–Brain Barrier Integrity
by: Daniel Bull, et al.
Published: (2022-01-01)

Generation of hiPSC-Derived Functional Dopaminergic Neurons in Alginate-Based 3D Culture
by: Valentina Gilmozzi, et al.
Published: (2021-08-01)

Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms
by: Agustín Cota-Coronado, et al.
Published: (2020-03-01)

Generation of hiPSCs with ABO c.767T>C substitution: resulting in splicing variants
by: Yinge Jin, et al.
Published: (2023-06-01)

One Billion hiPSC-Cardiomyocytes: Upscaling Engineered Cardiac Tissues to Create High Cell Density Therapies for Clinical Translation in Heart Regeneration
by: Kiera D. Dwyer, et al.
Published: (2023-05-01)