Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity
The current study evaluates the impact of high saturated fat feeding in rat model of experimental nephrotoxicity induced by gentamicin. Sprague-Dawley rats weighing 200 g were randomized into four groups; the first one received the standard rodents chow for 8 weeks and was treated as control, the s...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2012-02-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2527 |
| _version_ | 1797260904795996160 |
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| author | Zaid O. Ibraheem Munavvar A. Sattar Nor A. Abdullah Hassaan A. Rathore Edward J. Johns |
| author_facet | Zaid O. Ibraheem Munavvar A. Sattar Nor A. Abdullah Hassaan A. Rathore Edward J. Johns |
| author_sort | Zaid O. Ibraheem |
| collection | DOAJ |
| description |
The current study evaluates the impact of high saturated fat feeding in rat model of experimental nephrotoxicity induced by gentamicin. Sprague-Dawley rats weighing 200 g were randomized into four groups; the first one received the standard rodents chow for 8 weeks and was treated as control, the second group (HFD)received an experimental high fat diet rich in palm kernel oil (40% of Calories as fat) for the same period. The third group (HFDG) was given 80 mg/kg (body weight)/day gentamicin sulphate intraperitoneally during the last 24 days of the feeding period while the fourth group was given gentamicin as above along with the standard rodents chow. Renal function was assessed through measuring serum creatinine, creatinine clearance and absolute and fractional excretion of both sodium and potassium. At the end, rats underwent a surgical procedure for blood pressure measurement. Renal function study showed a stronger nephrotoxicity for HFDG group. Hypertension was observed in HFD group while the pressure declined after gentamicin co-administration. Overall, changing the feeding behavior toward using more SAFFAs for rats injected with gentamicin promotes the progression of renal failure.
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| first_indexed | 2024-04-24T23:32:44Z |
| format | Article |
| id | doaj.art-b0c6fdf7dca548499bc5bcdc9886310d |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:32:44Z |
| publishDate | 2012-02-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-b0c6fdf7dca548499bc5bcdc9886310d2024-03-15T14:33:45ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2012-02-0112110.17305/bjbms.2012.2527312Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicityZaid O. Ibraheem0Munavvar A. Sattar1Nor A. Abdullah2Hassaan A. Rathore3Edward J. Johns4School of Pharmaceutical Sciences, Universiti Sains MalaysiaSchool of Pharmaceutical Sciences, Universiti Sains MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti MalayaSchool of Pharmaceutical Sciences, Universiti Sains MalaysiaDepartment of Physiology, Aras Windle, University College Cork The current study evaluates the impact of high saturated fat feeding in rat model of experimental nephrotoxicity induced by gentamicin. Sprague-Dawley rats weighing 200 g were randomized into four groups; the first one received the standard rodents chow for 8 weeks and was treated as control, the second group (HFD)received an experimental high fat diet rich in palm kernel oil (40% of Calories as fat) for the same period. The third group (HFDG) was given 80 mg/kg (body weight)/day gentamicin sulphate intraperitoneally during the last 24 days of the feeding period while the fourth group was given gentamicin as above along with the standard rodents chow. Renal function was assessed through measuring serum creatinine, creatinine clearance and absolute and fractional excretion of both sodium and potassium. At the end, rats underwent a surgical procedure for blood pressure measurement. Renal function study showed a stronger nephrotoxicity for HFDG group. Hypertension was observed in HFD group while the pressure declined after gentamicin co-administration. Overall, changing the feeding behavior toward using more SAFFAs for rats injected with gentamicin promotes the progression of renal failure. https://www.bjbms.org/ojs/index.php/bjbms/article/view/2527nephrotoxicityblood pressurehypertensioncreatinine clearancehigh fat diet |
| spellingShingle | Zaid O. Ibraheem Munavvar A. Sattar Nor A. Abdullah Hassaan A. Rathore Edward J. Johns Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity Biomolecules & Biomedicine nephrotoxicity blood pressure hypertension creatinine clearance high fat diet |
| title | Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity |
| title_full | Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity |
| title_fullStr | Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity |
| title_full_unstemmed | Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity |
| title_short | Effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity |
| title_sort | effect of high saturated free fatty acids feeding on progression of renal failure in rat model of experimental nephrotoxicity |
| topic | nephrotoxicity blood pressure hypertension creatinine clearance high fat diet |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/2527 |
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