CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS

Correlation between purinenucleotides exchange and antioxidant system in patients with colorectal cancer (CC), as well as influence of key enzymes of purine decomposition on formation of active forms of oxygen were studied. During the process of study, enzymatic indicators of prooxidant system – ade...

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Main Authors: S. А. Zuikov, B. G. Borzenko, О. V. Zuikova
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2016-02-01
Series:Сибирский онкологический журнал
Subjects:
Online Access:https://www.siboncoj.ru/jour/article/view/27
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author S. А. Zuikov
B. G. Borzenko
О. V. Zuikova
author_facet S. А. Zuikov
B. G. Borzenko
О. V. Zuikova
author_sort S. А. Zuikov
collection DOAJ
description Correlation between purinenucleotides exchange and antioxidant system in patients with colorectal cancer (CC), as well as influence of key enzymes of purine decomposition on formation of active forms of oxygen were studied. During the process of study, enzymatic indicators of prooxidant system – adenosine deaminase and xanthineoxidase, as well as the level of nitric oxide were identified. Superoxidedismutase and glutathione peroxidase were the indicator of antiradical system. 22 patients aged 40–59 years with colorectal cancer of different stage were examined. A significant increase in indicators of prooxidant system in tissue homogenate of patients with CC and ambiguous changes in the activity of the antioxidant system, depending on the stage of the disease, were established. It was established that during the oxidative stress and in conditions of hypoxia, at the later stages of cancer, antioxidants may contribute to better survival ability of tumor cells and to more rapid tumor progression.
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spelling doaj.art-b0c7ce3c18a94e5a9bae509bc5fa56062023-03-13T09:05:46ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-0102242727CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORSS. А. Zuikov0B. G. Borzenko1О. V. Zuikova2Донецкий национальный медицинский университет им. М. Горького» г. ДонецкДонецкий национальный медицинский университет им. М. Горького» г. ДонецкДонецкий национальный медицинский университет им. М. Горького» г. ДонецкCorrelation between purinenucleotides exchange and antioxidant system in patients with colorectal cancer (CC), as well as influence of key enzymes of purine decomposition on formation of active forms of oxygen were studied. During the process of study, enzymatic indicators of prooxidant system – adenosine deaminase and xanthineoxidase, as well as the level of nitric oxide were identified. Superoxidedismutase and glutathione peroxidase were the indicator of antiradical system. 22 patients aged 40–59 years with colorectal cancer of different stage were examined. A significant increase in indicators of prooxidant system in tissue homogenate of patients with CC and ambiguous changes in the activity of the antioxidant system, depending on the stage of the disease, were established. It was established that during the oxidative stress and in conditions of hypoxia, at the later stages of cancer, antioxidants may contribute to better survival ability of tumor cells and to more rapid tumor progression.https://www.siboncoj.ru/jour/article/view/27ксантиноксидазааденозиндезаминазаоксид азотасупероксиддисмутазаглутатионпероксидазаколоректальный рак
spellingShingle S. А. Zuikov
B. G. Borzenko
О. V. Zuikova
CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS
Сибирский онкологический журнал
ксантиноксидаза
аденозиндезаминаза
оксид азота
супероксиддисмутаза
глутатионпероксидаза
колоректальный рак
title CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS
title_full CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS
title_fullStr CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS
title_full_unstemmed CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS
title_short CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS
title_sort correlation of pro oxidant with antioxidant systems in case of colorectal tumors
topic ксантиноксидаза
аденозиндезаминаза
оксид азота
супероксиддисмутаза
глутатионпероксидаза
колоректальный рак
url https://www.siboncoj.ru/jour/article/view/27
work_keys_str_mv AT sazuikov correlationofprooxidantwithantioxidantsystemsincaseofcolorectaltumors
AT bgborzenko correlationofprooxidantwithantioxidantsystemsincaseofcolorectaltumors
AT ovzuikova correlationofprooxidantwithantioxidantsystemsincaseofcolorectaltumors