Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind study
Background: The aim of this study was to assess whether intravenous dexamethasone was noninferior to perineural dexamethasone as an adjuvant to ropivacaine for a combination of saphenous and sciatic nerve blocks in patients undergoing foot and ankle surgery. Methods: This was a prospective, blinded,...
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Elsevier
2024-04-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024043354 |
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| author | Guiyu Lei Siliu Yang Lili Wu Yue Yin Shu Zhang Guyan Wang |
| author_facet | Guiyu Lei Siliu Yang Lili Wu Yue Yin Shu Zhang Guyan Wang |
| author_sort | Guiyu Lei |
| collection | DOAJ |
| description | Background: The aim of this study was to assess whether intravenous dexamethasone was noninferior to perineural dexamethasone as an adjuvant to ropivacaine for a combination of saphenous and sciatic nerve blocks in patients undergoing foot and ankle surgery. Methods: This was a prospective, blinded, randomized noninferiority study. Seventy-five patients, aged 18–75 years, with an American Society of Anesthesiologists (ASA) physical status I-III who underwent foot and ankle surgery were involved. Patients scheduled for ultrasound-guided popliteal sciatic nerve block and saphenous nerve block were randomized to receive 0.375% ropivacaine with 7.5 mg of dexamethasone perineurally (Dex-PN), 10 mg of dexamethasone intravenously (Dex-IV) or neither (Placebo). The primary outcome was the duration of analgesia. The major secondary outcomes were the composite pain intensity and opioid consumption score at 0–48 h intervals after anesthesia. Results: The mean analgesic duration was 26.2 h in the Dex-IV group and 27.9 h in the Dex-PN group (duration difference, −1.7; 95% CI, −3.8 to 0.43; P = 0.117), and both durations were significantly longer than that in the placebo group (17.6 h, P < 0.001). Conditions for establishing non-inferiority were met. Conclusions: Our findings indicate that a single 10-mg intravenous dose of dexamethasone was noninferior to the combined dose of ropivacaine plus deaxmethasone in terms of duration of analgesia for foot and ankle surgery. |
| first_indexed | 2024-04-24T18:47:43Z |
| format | Article |
| id | doaj.art-b0ca1c17313b4bb7ae48affdad961b6e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T18:47:43Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b0ca1c17313b4bb7ae48affdad961b6e2024-03-27T04:52:33ZengElsevierHeliyon2405-84402024-04-01107e28304Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind studyGuiyu Lei0Siliu Yang1Lili Wu2Yue Yin3Shu Zhang4Guyan Wang5Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Department of Anesthesiology, Beijing Dongcheng Maternal and Child Health Care Hospital, Beijing, 100007, ChinaDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaCenter of Foot and Ankle Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Corresponding author.Background: The aim of this study was to assess whether intravenous dexamethasone was noninferior to perineural dexamethasone as an adjuvant to ropivacaine for a combination of saphenous and sciatic nerve blocks in patients undergoing foot and ankle surgery. Methods: This was a prospective, blinded, randomized noninferiority study. Seventy-five patients, aged 18–75 years, with an American Society of Anesthesiologists (ASA) physical status I-III who underwent foot and ankle surgery were involved. Patients scheduled for ultrasound-guided popliteal sciatic nerve block and saphenous nerve block were randomized to receive 0.375% ropivacaine with 7.5 mg of dexamethasone perineurally (Dex-PN), 10 mg of dexamethasone intravenously (Dex-IV) or neither (Placebo). The primary outcome was the duration of analgesia. The major secondary outcomes were the composite pain intensity and opioid consumption score at 0–48 h intervals after anesthesia. Results: The mean analgesic duration was 26.2 h in the Dex-IV group and 27.9 h in the Dex-PN group (duration difference, −1.7; 95% CI, −3.8 to 0.43; P = 0.117), and both durations were significantly longer than that in the placebo group (17.6 h, P < 0.001). Conditions for establishing non-inferiority were met. Conclusions: Our findings indicate that a single 10-mg intravenous dose of dexamethasone was noninferior to the combined dose of ropivacaine plus deaxmethasone in terms of duration of analgesia for foot and ankle surgery.http://www.sciencedirect.com/science/article/pii/S2405844024043354Foot and ankle surgeryDexamethasoneNerve blockPerineuralIntravenous |
| spellingShingle | Guiyu Lei Siliu Yang Lili Wu Yue Yin Shu Zhang Guyan Wang Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind study Heliyon Foot and ankle surgery Dexamethasone Nerve block Perineural Intravenous |
| title | Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind study |
| title_full | Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind study |
| title_fullStr | Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind study |
| title_full_unstemmed | Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind study |
| title_short | Intravenous injection of dexamethasone is non-inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks: A randomized, controlled, triple-blind study |
| title_sort | intravenous injection of dexamethasone is non inferior to perineural administration for popliteal sciatic nerve and saphenous nerve blocks a randomized controlled triple blind study |
| topic | Foot and ankle surgery Dexamethasone Nerve block Perineural Intravenous |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024043354 |
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