Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.

Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.

The embryonic stem cell (ESC) factor, SALL4, plays an essential role in both development and leukemogenesis. It is a unique gene that is involved in self-renewal in ESC and leukemic stem cell (LSC).To understand the mechanism(s) of SALL4 function(s), we sought to identify SALL4-associated proteins b...

Full description

Bibliographic Details
Main Authors: Jiayun Lu, Ha-Won Jeong, Nikki Kong, Youyang Yang, John Carroll, Hongbo R Luo, Leslie E Silberstein, Yupoma, Li Chai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2679146?pdf=render

Similar Items

Similar Items