Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio
ABSTRACT Objective Prematurity and low birth weight predispose preterm infants to cardiovascular disease in later life. Is the metabolic profile of these children impacted by the relation between birth weight and gestational age (GA)? This study aimed to evaluate whether the relationship between b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2020-04-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000500567&tlng=en |
| _version_ | 1798015592995749888 |
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| author | Claudia Silveira Viera Grasiely Masotti Scalabrin Barreto Rita de Cassia Silveira Hugo Razzini Oliveira Beatriz Rosana Gonçalves de Oliveira Toso Milene Sedrez Rover Sabrina Grassioli Ana Tereza Bittencourt Guimarães Sandra Lucinei Balbo |
| author_facet | Claudia Silveira Viera Grasiely Masotti Scalabrin Barreto Rita de Cassia Silveira Hugo Razzini Oliveira Beatriz Rosana Gonçalves de Oliveira Toso Milene Sedrez Rover Sabrina Grassioli Ana Tereza Bittencourt Guimarães Sandra Lucinei Balbo |
| author_sort | Claudia Silveira Viera |
| collection | DOAJ |
| description | ABSTRACT Objective Prematurity and low birth weight predispose preterm infants to cardiovascular disease in later life. Is the metabolic profile of these children impacted by the relation between birth weight and gestational age (GA)? This study aimed to evaluate whether the relationship between birth weight and GA of preterm infants has a positive correlation with the metabolic profile from birth to the sixth month of corrected age. Subjects and methods This is a longitudinal, prospective study with a cohort of 70 preterm and 54 term infants, who were enrolled in the study and shared into two groups: Appropriate for GA (AGA) and Small for GA (SGA), both classified at birth by Fenton and Kim curves. Longitudinal evaluation of anthropometry measures and blood samples of total cholesterol, glucose, triglycerides, and insulin were collected at birth, NICU discharge, and the sixth month of corrected age. Data were analyzed using descriptive and inferential statistical analysis (ANOVA, Fisher test, Shapiro-Wilk, and Cochran test). The effect size was 0.15, power was 0.92, and confidence interval 95%. Results No significant statistical differences were observed in relation to biochemical tests between AGA and SGA groups. However, a significant increase in triglyceride results above the reference values for age in the SGA group was observed throughout the follow-up. Conclusions Changes observed in the preterm infant metabolic profile show no correlation with adequacy of birth weight. Preterm lipid profile requires continuous evaluation at follow-up, due to the increased cardiovascular risk in later life. |
| first_indexed | 2024-04-11T15:36:02Z |
| format | Article |
| id | doaj.art-b0ca9f5014ed483fbafafddf344d0481 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-11T15:36:02Z |
| publishDate | 2020-04-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-b0ca9f5014ed483fbafafddf344d04812022-12-22T04:15:57ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922020-04-0164556757410.20945/2359-3997000000237Biochemical predictors for metabolic syndrome in preterm infants according to weight ratioClaudia Silveira Vierahttps://orcid.org/0000-0002-0900-4660Grasiely Masotti Scalabrin Barretohttps://orcid.org/0000-0003-3491-0670Rita de Cassia Silveirahttps://orcid.org/0000-0002-2982-2652Hugo Razzini Oliveirahttps://orcid.org/0000-0003-2252-078XBeatriz Rosana Gonçalves de Oliveira Tosohttps://orcid.org/0000-0001-7366-077XMilene Sedrez Roverhttps://orcid.org/0000-0002-8873-8194Sabrina Grassiolihttps://orcid.org/0000-0001-5647-7877Ana Tereza Bittencourt Guimarãeshttps://orcid.org/0000-0002-3633-6484Sandra Lucinei Balbohttps://orcid.org/0000-0002-2866-3928ABSTRACT Objective Prematurity and low birth weight predispose preterm infants to cardiovascular disease in later life. Is the metabolic profile of these children impacted by the relation between birth weight and gestational age (GA)? This study aimed to evaluate whether the relationship between birth weight and GA of preterm infants has a positive correlation with the metabolic profile from birth to the sixth month of corrected age. Subjects and methods This is a longitudinal, prospective study with a cohort of 70 preterm and 54 term infants, who were enrolled in the study and shared into two groups: Appropriate for GA (AGA) and Small for GA (SGA), both classified at birth by Fenton and Kim curves. Longitudinal evaluation of anthropometry measures and blood samples of total cholesterol, glucose, triglycerides, and insulin were collected at birth, NICU discharge, and the sixth month of corrected age. Data were analyzed using descriptive and inferential statistical analysis (ANOVA, Fisher test, Shapiro-Wilk, and Cochran test). The effect size was 0.15, power was 0.92, and confidence interval 95%. Results No significant statistical differences were observed in relation to biochemical tests between AGA and SGA groups. However, a significant increase in triglyceride results above the reference values for age in the SGA group was observed throughout the follow-up. Conclusions Changes observed in the preterm infant metabolic profile show no correlation with adequacy of birth weight. Preterm lipid profile requires continuous evaluation at follow-up, due to the increased cardiovascular risk in later life.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000500567&tlng=enPremature infantlow birth weight infantlongitudinal studiesmetabolic syndrome |
| spellingShingle | Claudia Silveira Viera Grasiely Masotti Scalabrin Barreto Rita de Cassia Silveira Hugo Razzini Oliveira Beatriz Rosana Gonçalves de Oliveira Toso Milene Sedrez Rover Sabrina Grassioli Ana Tereza Bittencourt Guimarães Sandra Lucinei Balbo Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio Archives of Endocrinology and Metabolism Premature infant low birth weight infant longitudinal studies metabolic syndrome |
| title | Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio |
| title_full | Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio |
| title_fullStr | Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio |
| title_full_unstemmed | Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio |
| title_short | Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio |
| title_sort | biochemical predictors for metabolic syndrome in preterm infants according to weight ratio |
| topic | Premature infant low birth weight infant longitudinal studies metabolic syndrome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000500567&tlng=en |
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