IgG1 memory B cells keep the memory of IgE responses
IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells without additional somatic hyper...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00723-0 |
| _version_ | 1818857940941012992 |
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| author | Jin-Shu He Sharrada Subramaniam Vipin Narang Kandhadayar Srinivasan Sean P. Saunders Daniel Carbajo Tsao Wen-Shan Nur Hidayah Hamadee Josephine Lum Andrea Lee Jinmiao Chen Michael Poidinger Francesca Zolezzi Juan J. Lafaille Maria A. Curotto de Lafaille |
| author_facet | Jin-Shu He Sharrada Subramaniam Vipin Narang Kandhadayar Srinivasan Sean P. Saunders Daniel Carbajo Tsao Wen-Shan Nur Hidayah Hamadee Josephine Lum Andrea Lee Jinmiao Chen Michael Poidinger Francesca Zolezzi Juan J. Lafaille Maria A. Curotto de Lafaille |
| author_sort | Jin-Shu He |
| collection | DOAJ |
| description | IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells without additional somatic hypermutation. |
| first_indexed | 2024-12-19T08:48:23Z |
| format | Article |
| id | doaj.art-b0cb1457667e4bd2866daf4adcb12580 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:48:23Z |
| publishDate | 2017-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b0cb1457667e4bd2866daf4adcb125802022-12-21T20:28:48ZengNature PortfolioNature Communications2041-17232017-09-018111210.1038/s41467-017-00723-0IgG1 memory B cells keep the memory of IgE responsesJin-Shu He0Sharrada Subramaniam1Vipin Narang2Kandhadayar Srinivasan3Sean P. Saunders4Daniel Carbajo5Tsao Wen-Shan6Nur Hidayah Hamadee7Josephine Lum8Andrea Lee9Jinmiao Chen10Michael Poidinger11Francesca Zolezzi12Juan J. Lafaille13Maria A. Curotto de Lafaille14Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Division of Pulmonary, Critical Care and Sleep Medicine, Departments of Medicine and Cell Biology, New York University School of MedicineSingapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Singapore Immunology Network (SIgN)Skirball Institute and Department of Pathology, New York University School of MedicineSingapore Immunology Network (SIgN)IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells without additional somatic hypermutation.https://doi.org/10.1038/s41467-017-00723-0 |
| spellingShingle | Jin-Shu He Sharrada Subramaniam Vipin Narang Kandhadayar Srinivasan Sean P. Saunders Daniel Carbajo Tsao Wen-Shan Nur Hidayah Hamadee Josephine Lum Andrea Lee Jinmiao Chen Michael Poidinger Francesca Zolezzi Juan J. Lafaille Maria A. Curotto de Lafaille IgG1 memory B cells keep the memory of IgE responses Nature Communications |
| title | IgG1 memory B cells keep the memory of IgE responses |
| title_full | IgG1 memory B cells keep the memory of IgE responses |
| title_fullStr | IgG1 memory B cells keep the memory of IgE responses |
| title_full_unstemmed | IgG1 memory B cells keep the memory of IgE responses |
| title_short | IgG1 memory B cells keep the memory of IgE responses |
| title_sort | igg1 memory b cells keep the memory of ige responses |
| url | https://doi.org/10.1038/s41467-017-00723-0 |
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