PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDY
Objective: To study the effect of pentoxifylline versus placebo on venous leg ulcers with and without compression therapy. Methods and Methodology: Prospective study of factorial design, permitting the simultaneous evaluation of alternative pharmaceutical, bandaging, and dressings materials....
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| Format: | Article |
| Language: | English |
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Student's Journal of Health Research
2023-09-01
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| Series: | Student's Journal of Health Research Africa |
| Subjects: | |
| Online Access: | https://www.sjhresearchafrica.org/index.php/public-html/article/view/654 |
| _version_ | 1827787311141617664 |
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| author | Yasir Tajdar Sakshi Singh Ankit Raj Ayush Raj |
| author_facet | Yasir Tajdar Sakshi Singh Ankit Raj Ayush Raj |
| author_sort | Yasir Tajdar |
| collection | DOAJ |
| description |
Objective:
To study the effect of pentoxifylline versus placebo on venous leg ulcers with and without compression therapy.
Methods and Methodology:
Prospective study of factorial design, permitting the simultaneous evaluation of alternative pharmaceutical, bandaging, and dressings materials. The study took place at the Department of General Surgery, I.G.I.M.S., Patna. A total of 40 patients with confirmed venous ulcers were included, after excluding other major causal factors. Participants were randomly assigned to receive either pentoxifylline or placebo. The main outcome measure was the complete healing (full epithelialization) of all ulcers on the study leg.
Results:
Among the patients receiving placebo, 10 out of 19 (53%) achieved complete healing, while among those receiving pentoxifylline, 14 out of 21 (64%) achieved complete healing.
Conclusions:
The study found no significant difference in healing rates between patients taking pentoxifylline and those receiving placebo.
Recommendation:
It is compression therapy that heals the ulcer, not the dressing, so wherever possible the primary dressing of choice should be a simple knitted viscose one. This recommendation may not apply if the wound has high levels of exudate or slough.
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| first_indexed | 2024-03-11T16:47:29Z |
| format | Article |
| id | doaj.art-b0ccfa472ba04f4085f436d3000338ce |
| institution | Directory Open Access Journal |
| issn | 2709-9997 |
| language | English |
| last_indexed | 2024-03-11T16:47:29Z |
| publishDate | 2023-09-01 |
| publisher | Student's Journal of Health Research |
| record_format | Article |
| series | Student's Journal of Health Research Africa |
| spelling | doaj.art-b0ccfa472ba04f4085f436d3000338ce2023-10-22T07:49:06ZengStudent's Journal of Health ResearchStudent's Journal of Health Research Africa2709-99972023-09-014910.51168/sjhrafrica.v4i9.654PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDYYasir Tajdar0Sakshi Singh1Ankit Raj2Ayush Raj3Department of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Department of Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Department of Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Department of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India Objective: To study the effect of pentoxifylline versus placebo on venous leg ulcers with and without compression therapy. Methods and Methodology: Prospective study of factorial design, permitting the simultaneous evaluation of alternative pharmaceutical, bandaging, and dressings materials. The study took place at the Department of General Surgery, I.G.I.M.S., Patna. A total of 40 patients with confirmed venous ulcers were included, after excluding other major causal factors. Participants were randomly assigned to receive either pentoxifylline or placebo. The main outcome measure was the complete healing (full epithelialization) of all ulcers on the study leg. Results: Among the patients receiving placebo, 10 out of 19 (53%) achieved complete healing, while among those receiving pentoxifylline, 14 out of 21 (64%) achieved complete healing. Conclusions: The study found no significant difference in healing rates between patients taking pentoxifylline and those receiving placebo. Recommendation: It is compression therapy that heals the ulcer, not the dressing, so wherever possible the primary dressing of choice should be a simple knitted viscose one. This recommendation may not apply if the wound has high levels of exudate or slough. https://www.sjhresearchafrica.org/index.php/public-html/article/view/654Venous ulcerpentoxifyllinewound healingcompression therapyulcer size |
| spellingShingle | Yasir Tajdar Sakshi Singh Ankit Raj Ayush Raj PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDY Student's Journal of Health Research Africa Venous ulcer pentoxifylline wound healing compression therapy ulcer size |
| title | PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDY |
| title_full | PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDY |
| title_fullStr | PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDY |
| title_full_unstemmed | PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDY |
| title_short | PENTOXIFYLLINE'S IMPACT ON VENOUS ULCERS: A RANDOMISED STUDY |
| title_sort | pentoxifylline s impact on venous ulcers a randomised study |
| topic | Venous ulcer pentoxifylline wound healing compression therapy ulcer size |
| url | https://www.sjhresearchafrica.org/index.php/public-html/article/view/654 |
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