N-methylsansalvamide elicits antitumor effects in colon cancer cells in vitro and in vivo by regulating proliferation, apoptosis, and metastatic capacity

N-methylsansalvamide elicits antitumor effects in colon cancer cells in vitro and in vivo by regulating proliferation, apoptosis, and metastatic capacity

N-methylsansalvamide (MSSV), a cyclic pentadepsipeptide, was obtained from a strain of Fusarium solani f. radicicola. The current study investigated the anti-colorectal cancer effect of MSSV. MSSV exhibited the inhibition of the proliferation in HCT116 cells via induction of G0/G1 cell cycle arrest...

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Bibliographic Details
Main Authors: Juhee Park, Sung-Kwon Moon, Chan Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
N-methylsansalvamide
colon cancer
G0/G1 cell cycle
apoptosis
migration
invasion
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1146966/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1146966/full

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