The Role of IgA in Chronic Upper Airway Disease: Friend or Foe?
Chronic upper airway inflammation is amongst the most prevalent chronic disease entities in the Western world with prevalence around 30% (rhinitis) and 11% (rhinosinusitis). Chronic rhinitis and rhinosinusitis may severely impair the quality of life, leading to a significant socio-economic burden. I...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Allergy |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2022.852546/full |
| _version_ | 1819121570180759552 |
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| author | Alba Sánchez Montalvo Alba Sánchez Montalvo Sophie Gohy Sophie Gohy Sophie Gohy Philippe Rombaux Charles Pilette Charles Pilette Valérie Hox Valérie Hox |
| author_facet | Alba Sánchez Montalvo Alba Sánchez Montalvo Sophie Gohy Sophie Gohy Sophie Gohy Philippe Rombaux Charles Pilette Charles Pilette Valérie Hox Valérie Hox |
| author_sort | Alba Sánchez Montalvo |
| collection | DOAJ |
| description | Chronic upper airway inflammation is amongst the most prevalent chronic disease entities in the Western world with prevalence around 30% (rhinitis) and 11% (rhinosinusitis). Chronic rhinitis and rhinosinusitis may severely impair the quality of life, leading to a significant socio-economic burden. It becomes more and more clear that the respiratory mucosa which forms a physiological as well as chemical barrier for inhaled particles, plays a key role in maintaining homeostasis and driving disease. In a healthy state, the mucosal immune system provides protection against pathogens as well as maintains a tolerance toward non-harmful commensal microbes and benign environmental substances such as allergens. One of the most important players of the mucosal immune system is immunoglobulin (Ig) A, which is well-studied in gut research where it has emerged as a key factor in creating tolerance to potential food allergens and maintaining a healthy microbiome. Although, it is very likely that IgA plays a similar role at the level of the respiratory epithelium, very little research has been performed on the role of this protein in the airways, especially in chronic upper airway diseases. This review summarizes what is known about IgA in upper airway homeostasis, as well as in rhinitis and rhinosinusitis, including current and possible new treatments that may interfere with the IgA system. By doing so, we identify unmet needs in exploring the different roles of IgA in the upper airways required to find new biomarkers or therapeutic options for treating chronic rhinitis and rhinosinusitis. |
| first_indexed | 2024-12-22T06:38:39Z |
| format | Article |
| id | doaj.art-b0cf03815bce4cfa83fe9e5b4c9af84b |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-12-22T06:38:39Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-b0cf03815bce4cfa83fe9e5b4c9af84b2022-12-21T18:35:30ZengFrontiers Media S.A.Frontiers in Allergy2673-61012022-03-01310.3389/falgy.2022.852546852546The Role of IgA in Chronic Upper Airway Disease: Friend or Foe?Alba Sánchez Montalvo0Alba Sánchez Montalvo1Sophie Gohy2Sophie Gohy3Sophie Gohy4Philippe Rombaux5Charles Pilette6Charles Pilette7Valérie Hox8Valérie Hox9Pole of Pneumology, ENT and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain (UCLouvain), Brussels, BelgiumAllergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, BelgiumPole of Pneumology, ENT and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain (UCLouvain), Brussels, BelgiumDepartment of Pulmonology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumCystic Fibrosis Reference Center, Cliniques Universitaires Saint-Luc, Brussels, BelgiumDepartment of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumPole of Pneumology, ENT and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain (UCLouvain), Brussels, BelgiumDepartment of Pulmonology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumPole of Pneumology, ENT and Dermatology, Institute of Experimental and Clinical Research, Université Catholique de Louvain (UCLouvain), Brussels, BelgiumDepartment of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, BelgiumChronic upper airway inflammation is amongst the most prevalent chronic disease entities in the Western world with prevalence around 30% (rhinitis) and 11% (rhinosinusitis). Chronic rhinitis and rhinosinusitis may severely impair the quality of life, leading to a significant socio-economic burden. It becomes more and more clear that the respiratory mucosa which forms a physiological as well as chemical barrier for inhaled particles, plays a key role in maintaining homeostasis and driving disease. In a healthy state, the mucosal immune system provides protection against pathogens as well as maintains a tolerance toward non-harmful commensal microbes and benign environmental substances such as allergens. One of the most important players of the mucosal immune system is immunoglobulin (Ig) A, which is well-studied in gut research where it has emerged as a key factor in creating tolerance to potential food allergens and maintaining a healthy microbiome. Although, it is very likely that IgA plays a similar role at the level of the respiratory epithelium, very little research has been performed on the role of this protein in the airways, especially in chronic upper airway diseases. This review summarizes what is known about IgA in upper airway homeostasis, as well as in rhinitis and rhinosinusitis, including current and possible new treatments that may interfere with the IgA system. By doing so, we identify unmet needs in exploring the different roles of IgA in the upper airways required to find new biomarkers or therapeutic options for treating chronic rhinitis and rhinosinusitis.https://www.frontiersin.org/articles/10.3389/falgy.2022.852546/fullrhinitisrhinosinusitisallergypolypsepitheliummucosal immunity |
| spellingShingle | Alba Sánchez Montalvo Alba Sánchez Montalvo Sophie Gohy Sophie Gohy Sophie Gohy Philippe Rombaux Charles Pilette Charles Pilette Valérie Hox Valérie Hox The Role of IgA in Chronic Upper Airway Disease: Friend or Foe? Frontiers in Allergy rhinitis rhinosinusitis allergy polyps epithelium mucosal immunity |
| title | The Role of IgA in Chronic Upper Airway Disease: Friend or Foe? |
| title_full | The Role of IgA in Chronic Upper Airway Disease: Friend or Foe? |
| title_fullStr | The Role of IgA in Chronic Upper Airway Disease: Friend or Foe? |
| title_full_unstemmed | The Role of IgA in Chronic Upper Airway Disease: Friend or Foe? |
| title_short | The Role of IgA in Chronic Upper Airway Disease: Friend or Foe? |
| title_sort | role of iga in chronic upper airway disease friend or foe |
| topic | rhinitis rhinosinusitis allergy polyps epithelium mucosal immunity |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2022.852546/full |
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