Hepatopancreatic ganglioneuroma in a young dog: a case report
The clinical, pathological and immunohistochemical features of a hepatobiliary and pancreatic ganglioneuroma in a seven-month-old dog are described. The dog presented progressive weight loss, anorexia and abdominal pain. At laparoscopic examination numerous whitish nodules ranging from 0.5 to 1 cm i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2011-02-01
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| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201102-0006_hepatopancreatic-ganglioneuroma-in-a-young-dog-a-case-report.php |
| _version_ | 1797897682147082240 |
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| author | R. Zafra M.J. Bautista J. Perez P.J. Ginel R. Lucena |
| author_facet | R. Zafra M.J. Bautista J. Perez P.J. Ginel R. Lucena |
| author_sort | R. Zafra |
| collection | DOAJ |
| description | The clinical, pathological and immunohistochemical features of a hepatobiliary and pancreatic ganglioneuroma in a seven-month-old dog are described. The dog presented progressive weight loss, anorexia and abdominal pain. At laparoscopic examination numerous whitish nodules ranging from 0.5 to 1 cm in diameter were found in the peripancreatic tissues, the bile duct system and perihepatic tissues. Due to poor prognosis the dog was euthanized and necropsy was conducted. Tumour nodules were not noted in the other examined abdominal organs. Microscopically, the nodules were composed of large, well differentiated neurons embedded in an abundant stroma of nerve fibres and connective fibrous tissue. Through immunohistochemistry analysis, neurons were found to express neurofilaments and did not express S-100 protein. The histopathological and immunohistochemical features were consistent with a diagnosis of ganglioneuroma. This case is atypical as the majority of reported canine ganglioneuromas involve the gastrointestinal tract. The early age of the dog is also considered to be atypical for this tumour. |
| first_indexed | 2024-04-10T08:01:06Z |
| format | Article |
| id | doaj.art-b0d153318b9649f49a9cfcf421ae4be9 |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T08:01:06Z |
| publishDate | 2011-02-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-b0d153318b9649f49a9cfcf421ae4be92023-02-23T03:49:55ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922011-02-01562939610.17221/1578-VETMEDvet-201102-0006Hepatopancreatic ganglioneuroma in a young dog: a case reportR. Zafra0M.J. Bautista1J. Perez2P.J. Ginel3R. Lucena4Faculty of Veterinary Medicine, University of Cordoba, SpainFaculty of Veterinary Medicine, University of Cordoba, SpainFaculty of Veterinary Medicine, University of Cordoba, SpainFaculty of Veterinary Medicine, University of Cordoba, SpainFaculty of Veterinary Medicine, University of Cordoba, SpainThe clinical, pathological and immunohistochemical features of a hepatobiliary and pancreatic ganglioneuroma in a seven-month-old dog are described. The dog presented progressive weight loss, anorexia and abdominal pain. At laparoscopic examination numerous whitish nodules ranging from 0.5 to 1 cm in diameter were found in the peripancreatic tissues, the bile duct system and perihepatic tissues. Due to poor prognosis the dog was euthanized and necropsy was conducted. Tumour nodules were not noted in the other examined abdominal organs. Microscopically, the nodules were composed of large, well differentiated neurons embedded in an abundant stroma of nerve fibres and connective fibrous tissue. Through immunohistochemistry analysis, neurons were found to express neurofilaments and did not express S-100 protein. The histopathological and immunohistochemical features were consistent with a diagnosis of ganglioneuroma. This case is atypical as the majority of reported canine ganglioneuromas involve the gastrointestinal tract. The early age of the dog is also considered to be atypical for this tumour.https://vetmed.agriculturejournals.cz/artkey/vet-201102-0006_hepatopancreatic-ganglioneuroma-in-a-young-dog-a-case-report.phpganglioneuromadogimmunohistochemistryliverpancreas |
| spellingShingle | R. Zafra M.J. Bautista J. Perez P.J. Ginel R. Lucena Hepatopancreatic ganglioneuroma in a young dog: a case report Veterinární Medicína ganglioneuroma dog immunohistochemistry liver pancreas |
| title | Hepatopancreatic ganglioneuroma in a young dog: a case report |
| title_full | Hepatopancreatic ganglioneuroma in a young dog: a case report |
| title_fullStr | Hepatopancreatic ganglioneuroma in a young dog: a case report |
| title_full_unstemmed | Hepatopancreatic ganglioneuroma in a young dog: a case report |
| title_short | Hepatopancreatic ganglioneuroma in a young dog: a case report |
| title_sort | hepatopancreatic ganglioneuroma in a young dog a case report |
| topic | ganglioneuroma dog immunohistochemistry liver pancreas |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201102-0006_hepatopancreatic-ganglioneuroma-in-a-young-dog-a-case-report.php |
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