Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles
Objective: To describe and evaluate urinary hormone profiles in the luteal phase.Setting and Patients: Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center.Methods: Daily urinary hormonal assessment of lu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpubh.2018.00147/full |
| _version_ | 1818963607324459008 |
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| author | María Elena Alliende José Antonio Arraztoa Ulises Guajardo Fernando Mellado |
| author_facet | María Elena Alliende José Antonio Arraztoa Ulises Guajardo Fernando Mellado |
| author_sort | María Elena Alliende |
| collection | DOAJ |
| description | Objective: To describe and evaluate urinary hormone profiles in the luteal phase.Setting and Patients: Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center.Methods: Daily urinary hormonal assessment of luteinizing hormone, estrone glucuronide, and pregnanediol glucuronide. This was done during 3 or more cycles, with 78 completed cycles. Samples were analyzed by both crude levels and levels adjusted for the hormone excretion rate. Correlation between measured parameters (LH surge, vulvar mucus) was assessed with regard to their ability to detect presumed ovulation.Results: An upper, middle, and lower tercile range for the main urinary reproductive hormones was determined and a classification system of zones proposed, considering profiles over or under the 10th percentile. Adjustment for the urine excretion rate proved useful for interpreting individual samples; this was less necessary with multiple samples over time where trends could be determined. This serial evaluation, in at least two cycles, lowered the possibility of finding an isolated luteal phase defect and helped identify the recurrence of such. Vulvar mucus findings performed well in determining the timing of ovulation. Despite the proven fertility of the study population, lower luteal phase hormones were detected in both an isolated and, in some situations, recurrent manner.Conclusion: A feasible method is proposed to accurately, thoroughly and reproducibly study the luteal phase in order to evaluate and treat identified abnormalities in a properly timed, restorative manner. This preliminary study provides the basis for future research, correlating urinary hormones with clinical findings, particularly those of luteal phase defects. |
| first_indexed | 2024-12-20T12:47:54Z |
| format | Article |
| id | doaj.art-b0d3435079db490a8da048663b37b67f |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-20T12:47:54Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-b0d3435079db490a8da048663b37b67f2022-12-21T19:40:16ZengFrontiers Media S.A.Frontiers in Public Health2296-25652018-05-01610.3389/fpubh.2018.00147298004Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone ProfilesMaría Elena Alliende0José Antonio Arraztoa1Ulises Guajardo2Fernando Mellado3Programa de Cuidado y Estudio de la Fertilidad (PROCEF), Departamento de Obstetricia, Ginecología y Biología de la Reproducción, Universidad de los Andes, Santiago, ChilePrograma de Cuidado y Estudio de la Fertilidad (PROCEF), Departamento de Obstetricia, Ginecología y Biología de la Reproducción, Universidad de los Andes, Santiago, ChileFacultad de Medicina, Universidad de los Andes, Santiago, ChileFacultad de Medicina, Universidad de los Andes, Santiago, ChileObjective: To describe and evaluate urinary hormone profiles in the luteal phase.Setting and Patients: Twenty-five healthy fertile women, with regular ovulatory pattern cycles as assessed by temperature and cervical mucus, at a university based center.Methods: Daily urinary hormonal assessment of luteinizing hormone, estrone glucuronide, and pregnanediol glucuronide. This was done during 3 or more cycles, with 78 completed cycles. Samples were analyzed by both crude levels and levels adjusted for the hormone excretion rate. Correlation between measured parameters (LH surge, vulvar mucus) was assessed with regard to their ability to detect presumed ovulation.Results: An upper, middle, and lower tercile range for the main urinary reproductive hormones was determined and a classification system of zones proposed, considering profiles over or under the 10th percentile. Adjustment for the urine excretion rate proved useful for interpreting individual samples; this was less necessary with multiple samples over time where trends could be determined. This serial evaluation, in at least two cycles, lowered the possibility of finding an isolated luteal phase defect and helped identify the recurrence of such. Vulvar mucus findings performed well in determining the timing of ovulation. Despite the proven fertility of the study population, lower luteal phase hormones were detected in both an isolated and, in some situations, recurrent manner.Conclusion: A feasible method is proposed to accurately, thoroughly and reproducibly study the luteal phase in order to evaluate and treat identified abnormalities in a properly timed, restorative manner. This preliminary study provides the basis for future research, correlating urinary hormones with clinical findings, particularly those of luteal phase defects.https://www.frontiersin.org/article/10.3389/fpubh.2018.00147/fullluteal phaseluteal phase deficiencyluteinizing hormoneestrone glucuronidepregnandiol glucuronideovulation detection |
| spellingShingle | María Elena Alliende José Antonio Arraztoa Ulises Guajardo Fernando Mellado Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles Frontiers in Public Health luteal phase luteal phase deficiency luteinizing hormone estrone glucuronide pregnandiol glucuronide ovulation detection |
| title | Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles |
| title_full | Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles |
| title_fullStr | Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles |
| title_full_unstemmed | Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles |
| title_short | Towards the Clinical Evaluation of the Luteal Phase in Fertile Women: A Preliminary Study of Normative Urinary Hormone Profiles |
| title_sort | towards the clinical evaluation of the luteal phase in fertile women a preliminary study of normative urinary hormone profiles |
| topic | luteal phase luteal phase deficiency luteinizing hormone estrone glucuronide pregnandiol glucuronide ovulation detection |
| url | https://www.frontiersin.org/article/10.3389/fpubh.2018.00147/full |
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