Runx1 loss minimally impacts long-term hematopoietic stem cells.

Runx1 loss minimally impacts long-term hematopoietic stem cells.

RUNX1 encodes a DNA binding subunit of the core-binding transcription factors and is frequently mutated in acute leukemia, therapy-related leukemia, myelodysplastic syndrome, and chronic myelomonocytic leukemia. Mutations in RUNX1 are thought to confer upon hematopoietic stem cells (HSCs) a pre-leuk...

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Bibliographic Details
Main Authors: Xiongwei Cai, Justin J Gaudet, James K Mangan, Michael J Chen, Maria Elena De Obaldia, Zaw Oo, Patricia Ernst, Nancy A Speck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3228772?pdf=render

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