Interplay between oxidant species and energy metabolism
It has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-08-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231715300112 |
| _version_ | 1818979955132858368 |
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| author | Celia Quijano Madia Trujillo Laura Castro Andrés Trostchansky |
| author_facet | Celia Quijano Madia Trujillo Laura Castro Andrés Trostchansky |
| author_sort | Celia Quijano |
| collection | DOAJ |
| description | It has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in the onset and progression of many age-related diseases (i.e. diabetes, metabolic syndrome, atherosclerosis, neurodegenerative diseases). As such, the capacity to identify metabolic pathways involved in ROS formation, as well as specific targets and oxidative modifications is crucial to our understanding of the molecular basis of age-related diseases and for the design of novel therapeutic strategies.
Herein we review oxidant formation associated with the cell's energetic metabolism, key antioxidants involved in ROS detoxification, and the principal targets of oxidant species in metabolic routes and discuss their relevance in cell signaling and age-related diseases. |
| first_indexed | 2024-12-20T17:07:45Z |
| format | Article |
| id | doaj.art-b0d50764337043939006d4e0d9604928 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-20T17:07:45Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-b0d50764337043939006d4e0d96049282022-12-21T19:32:14ZengElsevierRedox Biology2213-23172016-08-018C284210.1016/j.redox.2015.11.010Interplay between oxidant species and energy metabolismCelia QuijanoMadia TrujilloLaura CastroAndrés TrostchanskyIt has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in the onset and progression of many age-related diseases (i.e. diabetes, metabolic syndrome, atherosclerosis, neurodegenerative diseases). As such, the capacity to identify metabolic pathways involved in ROS formation, as well as specific targets and oxidative modifications is crucial to our understanding of the molecular basis of age-related diseases and for the design of novel therapeutic strategies. Herein we review oxidant formation associated with the cell's energetic metabolism, key antioxidants involved in ROS detoxification, and the principal targets of oxidant species in metabolic routes and discuss their relevance in cell signaling and age-related diseases.http://www.sciencedirect.com/science/article/pii/S2213231715300112Reactive oxygen speciesEnergy metabolismMitochondriaReactive nitrogen species |
| spellingShingle | Celia Quijano Madia Trujillo Laura Castro Andrés Trostchansky Interplay between oxidant species and energy metabolism Redox Biology Reactive oxygen species Energy metabolism Mitochondria Reactive nitrogen species |
| title | Interplay between oxidant species and energy metabolism |
| title_full | Interplay between oxidant species and energy metabolism |
| title_fullStr | Interplay between oxidant species and energy metabolism |
| title_full_unstemmed | Interplay between oxidant species and energy metabolism |
| title_short | Interplay between oxidant species and energy metabolism |
| title_sort | interplay between oxidant species and energy metabolism |
| topic | Reactive oxygen species Energy metabolism Mitochondria Reactive nitrogen species |
| url | http://www.sciencedirect.com/science/article/pii/S2213231715300112 |
| work_keys_str_mv | AT celiaquijano interplaybetweenoxidantspeciesandenergymetabolism AT madiatrujillo interplaybetweenoxidantspeciesandenergymetabolism AT lauracastro interplaybetweenoxidantspeciesandenergymetabolism AT andrestrostchansky interplaybetweenoxidantspeciesandenergymetabolism |