Phenome-wide and genome-wide analyses of quality of life in schizophrenia
Background Schizophrenia negatively affects quality of life (QoL). A handful of variables from small studies have been reported to influence QoL in patients with schizophrenia, but a study comprehensively dissecting the genetic and non-genetic contributing factors to QoL in these patients is current...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-01-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472420001404/type/journal_article |
| _version_ | 1811156934183616512 |
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| author | Raha Pazoki Bochao Danae Lin Kristel R. van Eijk Dick Schijven Sonja de Zwarte Sinan Guloksuz Jurjen J. Luykx |
| author_facet | Raha Pazoki Bochao Danae Lin Kristel R. van Eijk Dick Schijven Sonja de Zwarte Sinan Guloksuz Jurjen J. Luykx |
| author_sort | Raha Pazoki |
| collection | DOAJ |
| description | Background
Schizophrenia negatively affects quality of life (QoL). A handful of variables from small studies have been reported to influence QoL in patients with schizophrenia, but a study comprehensively dissecting the genetic and non-genetic contributing factors to QoL in these patients is currently lacking.
Aims
We adopted a hypothesis-generating approach to assess the phenotypic and genotypic determinants of QoL in schizophrenia.
Method
The study population comprised 1119 patients with a psychotic disorder, 1979 relatives and 586 healthy controls. Using linear regression, we tested >100 independent demographic, cognitive and clinical phenotypes for their association with QoL in patients. We then performed genome-wide association analyses of QoL and examined the association between polygenic risk scores for schizophrenia, major depressive disorder and subjective well-being and QoL.
Results
We found nine phenotypes to be significantly and independently associated with QoL in patients, the most significant ones being negative (β = −1.17; s.e. 0.05; P = 1 × 10–83; r2 = 38%), depressive (β = −1.07; s.e. 0.05; P = 2 × 10–79; r2 = 36%) and emotional distress (β = −0.09; s.e. 0.01; P = 4 × 10–59, r2 = 25%) symptoms. Schizophrenia and subjective well-being polygenic risk scores, using various P-value thresholds, were significantly and consistently associated with QoL (lowest association P-value = 6.8 × 10–6). Several sensitivity analyses confirmed the results.
Conclusions
Various clinical phenotypes of schizophrenia, as well as schizophrenia and subjective well-being polygenic risk scores, are associated with QoL in patients with schizophrenia and their relatives. These may be targeted by clinicians to more easily identify vulnerable patients with schizophrenia for further social and clinical interventions to improve their QoL.
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| first_indexed | 2024-04-10T04:59:27Z |
| format | Article |
| id | doaj.art-b0d5477a2a7c4c488b36034bf8388baa |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T04:59:27Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-b0d5477a2a7c4c488b36034bf8388baa2023-03-09T12:29:06ZengCambridge University PressBJPsych Open2056-47242021-01-01710.1192/bjo.2020.140Phenome-wide and genome-wide analyses of quality of life in schizophreniaRaha Pazoki0Bochao Danae Lin1Kristel R. van Eijk2Dick Schijven3Sonja de Zwarte4Sinan Guloksuz5Jurjen J. Luykx6https://orcid.org/0000-0002-6439-2774Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; and Department of Epidemiology, Imperial College London, School of Public Health, UKDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; and Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The NetherlandsDepartment of Psychiatry and Neuropsychology, Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, The Netherlands; and Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USADepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands; and Outpatient Second Opinion Clinic, GGNet, Warnsveld, The NetherlandsBackground Schizophrenia negatively affects quality of life (QoL). A handful of variables from small studies have been reported to influence QoL in patients with schizophrenia, but a study comprehensively dissecting the genetic and non-genetic contributing factors to QoL in these patients is currently lacking. Aims We adopted a hypothesis-generating approach to assess the phenotypic and genotypic determinants of QoL in schizophrenia. Method The study population comprised 1119 patients with a psychotic disorder, 1979 relatives and 586 healthy controls. Using linear regression, we tested >100 independent demographic, cognitive and clinical phenotypes for their association with QoL in patients. We then performed genome-wide association analyses of QoL and examined the association between polygenic risk scores for schizophrenia, major depressive disorder and subjective well-being and QoL. Results We found nine phenotypes to be significantly and independently associated with QoL in patients, the most significant ones being negative (β = −1.17; s.e. 0.05; P = 1 × 10–83; r2 = 38%), depressive (β = −1.07; s.e. 0.05; P = 2 × 10–79; r2 = 36%) and emotional distress (β = −0.09; s.e. 0.01; P = 4 × 10–59, r2 = 25%) symptoms. Schizophrenia and subjective well-being polygenic risk scores, using various P-value thresholds, were significantly and consistently associated with QoL (lowest association P-value = 6.8 × 10–6). Several sensitivity analyses confirmed the results. Conclusions Various clinical phenotypes of schizophrenia, as well as schizophrenia and subjective well-being polygenic risk scores, are associated with QoL in patients with schizophrenia and their relatives. These may be targeted by clinicians to more easily identify vulnerable patients with schizophrenia for further social and clinical interventions to improve their QoL. https://www.cambridge.org/core/product/identifier/S2056472420001404/type/journal_articleQuality of lifeschizophreniaphenomegenomepolygenic |
| spellingShingle | Raha Pazoki Bochao Danae Lin Kristel R. van Eijk Dick Schijven Sonja de Zwarte Sinan Guloksuz Jurjen J. Luykx Phenome-wide and genome-wide analyses of quality of life in schizophrenia BJPsych Open Quality of life schizophrenia phenome genome polygenic |
| title | Phenome-wide and genome-wide analyses of quality of life in schizophrenia |
| title_full | Phenome-wide and genome-wide analyses of quality of life in schizophrenia |
| title_fullStr | Phenome-wide and genome-wide analyses of quality of life in schizophrenia |
| title_full_unstemmed | Phenome-wide and genome-wide analyses of quality of life in schizophrenia |
| title_short | Phenome-wide and genome-wide analyses of quality of life in schizophrenia |
| title_sort | phenome wide and genome wide analyses of quality of life in schizophrenia |
| topic | Quality of life schizophrenia phenome genome polygenic |
| url | https://www.cambridge.org/core/product/identifier/S2056472420001404/type/journal_article |
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