Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.

Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.

The mammalian kynurenine aminotransferase (KAT) enzymes are a family of related isoforms that are pyridoxal 5'-phosphate-dependent, responsible for the irreversible transamination of kynurenine to kynurenic acid. Kynurenic acid is implicated in human diseases such as schizophrenia where it is f...

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Bibliographic Details
Main Authors: Gayan S Jayawickrama, Alireza Nematollahi, Guanchen Sun, William Bret Church
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5915280?pdf=render

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